Nanoparticulate Poly(glucaramide)-Based Hydrogels for Controlled Release Applications
Abstract
:1. Introduction
2. Results and Discussion
2.1. Synthesis of Poly(glucaramide)s
2.2. Preparation of Hydrogels
2.3. Characterization of Hydrogels
2.3.1. SEM Characterization
2.3.2. DLS Analyses
2.3.3. Rheological Characterization
2.4. Controlled Release of STPP
3. Conclusions
4. Materials and Methods
4.1. Reagents and Materials
4.2. Synthesis of Poly(glucaramide)s
4.3. Preparation of Poly(glucaramide) Hydrogels
4.4. Hydrogel Characterization
4.4.1. Scanning Electron Microscopy (SEM)
4.4.2. Dynamic Light Scattering (DLS)
4.4.3. Rheological Characterization
4.5. Sodium Tripolyphosphate (STPP) Release Studies
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Poly(glucaramide) | Water Solubility | Gel Formation | Minimum Gelling Concentration (MGC, % w/w) | Solvent |
---|---|---|---|---|
Poly(tetramethylene d-glucaramide) (C4) | Yes | No | N/A | N/A |
Poly(tetramethylene/hexamethylene d-glucaramide) (C4C6) | Partial | Yes | 2.5% | Water |
Poly(hexamethylene d-glucaramide) (C6) | No | Yes | 1% | Acetic acid (20% v/v) |
Time (h) | C4 | C4C6 | C6 | |||
---|---|---|---|---|---|---|
Particle Size (Diameter, nm) | Intensity * (%) | Particle Size (Diameter, nm) | Intensity * (%) | Particle Size (Diameter, nm) | Intensity * (%) | |
0 | 4.3 ± 1.6 148.4 ± 83.8 4065 ± 1060 | 76.6 22.3 1.0 | 4.5 ± 1.4 218.1 ± 118.1 4468 ± 897.9 | 65.8 33.2 1.0 | 3.9 ± 1.6 4429 ± 921.3 | 94.8 5.2 |
1 | 4.3 ± 1.8 124.8 ± 55.6 5032 ± 593.8 | 75.2 21.8 3.0 | 4.1 ± 1.1 387.2 ± 361.2 3709 ± 1061 | 60.4 37.6 2.0 | 3.8 ± 0.8 2304 ± 382.2 | 18.4 81.6 |
3 | 4.3 ± 1.6 175.4 ± 97.4 | 78.8 21.2 | 4.1 ± 1.3 68.2 ± 28.5 700.2 ± 412.4 | 40.7 4.9 54.4 | ND | ND |
Polymer Concentration (% w/w) | TG→L (°C) | |
---|---|---|
C4C6 | C6 | |
1 | Not tested | 85.5 ± 0.5 |
2.5 | 100.4 ± 0.7 | 93.0 ± 0.7 |
5 | 103.7 ± 0.3 | 101.0 ± 1.4 |
10 | 107.3 ± 0.5 | Not tested |
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Johnston, E.R.; Smith, T.N.; Serban, M.A. Nanoparticulate Poly(glucaramide)-Based Hydrogels for Controlled Release Applications. Gels 2017, 3, 17. https://doi.org/10.3390/gels3020017
Johnston ER, Smith TN, Serban MA. Nanoparticulate Poly(glucaramide)-Based Hydrogels for Controlled Release Applications. Gels. 2017; 3(2):17. https://doi.org/10.3390/gels3020017
Chicago/Turabian StyleJohnston, Erik R., Tyler N. Smith, and Monica A. Serban. 2017. "Nanoparticulate Poly(glucaramide)-Based Hydrogels for Controlled Release Applications" Gels 3, no. 2: 17. https://doi.org/10.3390/gels3020017