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Design of Hybrid Gels Based on Gellan-Cholesterol Derivative and P90G Liposomes for Drug Depot Applications

Department of Drug Chemistry and Technologies, Sapienza, University of Roma, P.le A. Moro 5, 00185 Roma, Italy
Department of Scienze della Vita e dell’Ambiente, University of Cagliari, via Ospedale 72, 09124 Cagliari, Italy
Author to whom correspondence should be addressed.
Academic Editor: Gaio Paradossi
Received: 28 February 2017 / Revised: 26 April 2017 / Accepted: 3 May 2017 / Published: 8 May 2017
(This article belongs to the Special Issue Micro- and Nanogels)
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Gels are extensively studied in the drug delivery field because of their potential benefits in therapeutics. Depot gel systems fall in this area, and the interest in their development has been focused on long-lasting, biocompatible, and resorbable delivery devices. The present work describes a new class of hybrid gels that stem from the interaction between liposomes based on P90G phospholipid and the cholesterol derivative of the polysaccharide gellan. The mechanical properties of these gels and the delivery profiles of the anti-inflammatory model drug diclofenac embedded in such systems confirmed the suitability of these hybrid gels as a good candidate for drug depot applications. View Full-Text
Keywords: P90G liposomes; gellan–cholesterol; hydrogel; depot; drug delivery P90G liposomes; gellan–cholesterol; hydrogel; depot; drug delivery

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zoratto, N.; Palmieri, F.R.; Cencetti, C.; Montanari, E.; Di Meo, C.; Manca, M.L.; Manconi, M.; Matricardi, P. Design of Hybrid Gels Based on Gellan-Cholesterol Derivative and P90G Liposomes for Drug Depot Applications. Gels 2017, 3, 18.

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