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Nanoparticulate Poly(glucaramide)-Based Hydrogels for Controlled Release Applications

Materials Science Program, University of Montana, 32 Campus Dr., Missoula, MT 59812, USA
Rivertop Renewables, 1121 E Broadway St # 135, Missoula, MT 59802, USA
Department of Biomedical and Pharmaceutical Sciences, University of Montana, 32 Campus Dr., Missoula, MT 59812, USA
Author to whom correspondence should be addressed.
Academic Editor: Damien Dupin
Received: 28 March 2017 / Revised: 28 April 2017 / Accepted: 2 May 2017 / Published: 6 May 2017
(This article belongs to the Special Issue Hydrogels Based on Dynamic Covalent Chemistry)
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In 2004, D-Glucaric acid (GA) was identified as one of the top value-added chemicals from renewable feedstocks. For this study, a patented synthetic method was used to obtain gel forming polymers through the polycondensation of GA and several aliphatic diamines. The first time characterization and a potential practical application of such hydrogels is reported herein. Our findings indicate that the physical properties and gelling abilities of these materials correlate with the chemical structure of the precursor diamines used for polymerization. The hydrogels appear to have nanoparticulate nature, form via aggregation, are thermoresponsive, and appear suitable as controlled release systems for small molecules. Overall, this study further highlights the versatility of GA as a building block for the synthesis of sustainable materials, with potential for a wide array of applications. View Full-Text
Keywords: D-Glucaric acid; polymers; nanoparticles; hydrogel; controlled release D-Glucaric acid; polymers; nanoparticles; hydrogel; controlled release

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Johnston, E.R.; Smith, T.N.; Serban, M.A. Nanoparticulate Poly(glucaramide)-Based Hydrogels for Controlled Release Applications. Gels 2017, 3, 17.

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