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Gels 2015, 1(2), 194-218;

Grafting Techniques towards Production of Peptide-Tethered Hydrogels, a Novel Class of Materials with Biomedical Interest

UCIBIO-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, P-4169-007 Porto, Portugal
Instituto de Investigação e Inovação em Saúde, Universidade do Porto, P-4200-135 Porto, Portugal
INEB-Instituto de Engenharia Biomédica, Universidade do Porto, P-4150-180 Porto, Portugal
Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, P-4169-007 Porto, Portugal
Author to whom correspondence should be addressed.
Academic Editor: Rolando Barbucci
Received: 23 July 2015 / Revised: 1 October 2015 / Accepted: 13 October 2015 / Published: 21 October 2015
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In recent years, new highly functional polymeric biomaterials are being developed to increase the therapeutic efficacy in tissue regeneration approaches. Peptides regulate most physiological processes and display several other biological activities. Therefore, their importance in the field of biomedical research and drug development is rapidly increasing. However, the use of peptides as therapeutic agents is restricted by some of their physicochemical properties. The development of improved routes of delivery of peptide-based therapeutics is crucial and is crucial and its biomedical value is expected to increase in the near future. The unique properties of hydrogels triggered their spreading as localized drug depots. Several strategies, such as the carbodiimide chemistry, have been used to successfully immobilize bioactive peptide sequences into the hydrogels backbone. Peptide tethering through the so-called “click” chemistry reactions is also a highly promising, yet underexplored, approach to the synthesis of hydrogels with varying dimensions and patterns. The present review focus on the approaches that are being used for the establishment of chemical bonds between peptides and non-peptidic hydrogels throughout the last decade. View Full-Text
Keywords: hydrogels; functionalization; peptides; tissue engineering hydrogels; functionalization; peptides; tissue engineering

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Barbosa, M.; Martins, M.C.L.; Gomes, P. Grafting Techniques towards Production of Peptide-Tethered Hydrogels, a Novel Class of Materials with Biomedical Interest. Gels 2015, 1, 194-218.

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