Next Article in Journal / Special Issue
Precise Control over the Rheological Behavior of Associating Stimuli-Responsive Block Copolymer Gels
Previous Article in Journal
Grafting Techniques towards Production of Peptide-Tethered Hydrogels, a Novel Class of Materials with Biomedical Interest
Previous Article in Special Issue
Synthesis and Properties of New “Stimuli” Responsive Nanocomposite Hydrogels Containing Silver Nanoparticles
Article Menu

Export Article

Open AccessArticle
Gels 2015, 1(2), 219-234; doi:10.3390/gels1020219

Swelling Dynamics of a DNA-Polymer Hybrid Hydrogel Prepared Using Polyethylene Glycol as a Porogen

Biophysics and Medical Technology, Department of Physics, The Norwegian University of Science and Technology, Trondheim NO-7491, Norway
*
Author to whom correspondence should be addressed.
Academic Editor: Dirk Kuckling
Received: 7 September 2015 / Revised: 26 October 2015 / Accepted: 12 November 2015 / Published: 18 November 2015
(This article belongs to the Special Issue Stimuli-Responsive Gels)
View Full-Text   |   Download PDF [4303 KB, uploaded 18 November 2015]   |  

Abstract

DNA-polyacrylamide hybrid hydrogels designed with covalent and double-stranded (dsDNA) crosslinks respond to specific single-stranded DNA (ssDNA) probes by adapting new equilibrium swelling volume. The ssDNA probes need to be designed with a base pair sequence that is complementary to one of the strands in a dsDNA supported network junction. This work focuses on tuning the hydrogel swelling kinetics by introducing polyethylene glycol (PEG) as a pore-forming agent. Adding PEG during the preparation of hydrogels, followed by removal after polymerization, has been shown to improve the swelling dynamics of DNA hybrid hydrogels upon specific ssDNA probe recognition. The presence of porogen did not influence the kinetics of osmotic pressure-driven (2-acrylamido-2-methylpropane sulfonic acid)-co-acrylamide (AMPSA-co-AAm) hydrogels’ swelling, which is in contrast to the DNA-sensitive hydrogels. The difference in the effect of using PEG as a porogen in these two cases is discussed in view of processes leading to the swelling of the gels. View Full-Text
Keywords: DNA competitive displacement; hydrogel swelling; interferometric readout; nanometer resolution; PEG porogen DNA competitive displacement; hydrogel swelling; interferometric readout; nanometer resolution; PEG porogen
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Gao, M.; Gawel, K.; Stokke, B.T. Swelling Dynamics of a DNA-Polymer Hybrid Hydrogel Prepared Using Polyethylene Glycol as a Porogen. Gels 2015, 1, 219-234.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Gels EISSN 2310-2861 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top