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J. Fungi 2018, 4(3), 100; https://doi.org/10.3390/jof4030100

Immunity and Treatment of Sporotrichosis

Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Noria Alta s/n, col. Noria Alta, C.P., Guanajuato Gto. 36050, Mexico
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Received: 18 July 2018 / Revised: 18 August 2018 / Accepted: 19 August 2018 / Published: 20 August 2018
(This article belongs to the Special Issue Sporothrix and Sporotrichosis)
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Abstract

Species of the Sporothrix complex are the etiological agents of sporotrichosis, an important subcutaneous mycosis with several clinical forms and an increasing incidence around the world that affects humans and other mammals. The immunological mechanisms involved in the prevention and control of this mycosis are not entirely understood. Many reports have suggested that cell-mediated immunity has an essential role in the development of the disease, being the primary response controlling it, while only recent data supports that the humoral response is essential for the appropriate control. This mycosis is a challenge for diagnosis since the culture and isolation of the organism are time-consuming and complicated; reasons that have led to the study of fungus antigenic molecules capable of generating a detectable humoral response. The treatment for this disease includes the use of several antifungal drugs like itraconazole, amphotericin B, caspofungin, fluconazole, and the combination between them among others such as the extract of Vismia guianensis. View Full-Text
Keywords: immunity; sporotrichosis; host-defense; antifungal immunity; sporotrichosis; host-defense; antifungal
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García Carnero, L.C.; Lozoya Pérez, N.E.; González Hernández, S.E.; Martínez Álvarez, J.A. Immunity and Treatment of Sporotrichosis. J. Fungi 2018, 4, 100.

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