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J. Fungi 2017, 3(2), 25; doi:10.3390/jof3020025

NK Cells and Their Role in Invasive Mold Infection

1
Division of Pediatric Hematology and Oncology, Hospital for Children and Adolescents, Johann Wolfgang Goethe-University, Frankfurt 60590, Germany
2
Department of Clinical and Experimental Medicine, Unit of Pediatric Hematology and Oncology, University of Catania, Catania 95131, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Adilia Warris
Received: 19 April 2017 / Revised: 16 May 2017 / Accepted: 17 May 2017 / Published: 19 May 2017
(This article belongs to the Special Issue Host–Fungus Interactions)
View Full-Text   |   Download PDF [224 KB, uploaded 19 May 2017]

Abstract

There is growing evidence that Natural Killer (NK) cells exhibit in vitro activity against both Aspergillus and non-Aspergillus molds. Cytotoxic molecules such as NK cell-derived perforin seem to play an important role in the antifungal activity. In addition, NK cells release a number of cytokines upon stimulation by fungi, which modulate both innate and adaptive host immune responses. Whereas the in vitro data of the antifungal activity of NK cells are supported by animal studies, clinical data are scarce to date. View Full-Text
Keywords: NK cells; mold infection; host fungus interactions; lymphocytes NK cells; mold infection; host fungus interactions; lymphocytes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Schmidt, S.; Condorelli, A.; Koltze, A.; Lehrnbecher, T. NK Cells and Their Role in Invasive Mold Infection. J. Fungi 2017, 3, 25.

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