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J. Fungi 2017, 3(1), 10; doi:10.3390/jof3010010

The Crucial Role of Biofilms in Cryptococcus neoformans Survival within Macrophages and Colonization of the Central Nervous System

1
Department of Biomedical Sciences, NYIT College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, NY 11568-8000, USA
2
Howard University College of Medicine, Washington, DC 20059-1027, USA
3
Public Health Research Institute and Department of Microbiology and Molecular Genetics, New Jersey Medical School, Rutgers University, Newark, NJ 07103-9998, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Mahmoud A. Ghannoum
Received: 18 January 2017 / Revised: 9 February 2017 / Accepted: 21 February 2017 / Published: 24 February 2017
(This article belongs to the Special Issue Fungal Biofilms)
View Full-Text   |   Download PDF [1341 KB, uploaded 24 February 2017]   |  

Abstract

Cryptococcus neoformans is an encapsulated yeast-like fungus capable of causing life threatening meningoencephalitis in patients with impaired immunity. This microbe primarily infects the host via inhalation but has the ability to disseminate to the central nervous system (CNS) either as a single cell or inside of macrophages. Upon traversing the blood brain barrier, C. neoformans has the capacity to form biofilm-like structures known as cryptococcomas. Hence, we will discuss the C. neoformans elements contributing to biofilm formation including the fungus’ ability to survive in the acidic environment of a macrophage phagosome and inside of the CNS. The purpose of this mini-review is to instill fresh interest in understanding the importance of biofilms on fungal pathogenesis. View Full-Text
Keywords: biofilms; CNS; Cryptococcus neoformans; cryptococcomas; macrophages biofilms; CNS; Cryptococcus neoformans; cryptococcomas; macrophages
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Aslanyan, L.; Sanchez, D.A.; Valdebenito, S.; Eugenin, E.A.; Ramos, R.L.; Martinez, L.R. The Crucial Role of Biofilms in Cryptococcus neoformans Survival within Macrophages and Colonization of the Central Nervous System. J. Fungi 2017, 3, 10.

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