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J. Fungi 2016, 2(4), 29; doi:10.3390/jof2040029

Virulence Factors as Targets for Anticryptococcal Therapy

1
Fundação Oswaldo Cruz—Fiocruz, Centro de Desenvolvimento Tecnológico em Saúde (CDTS), 21040-361 Rio de Janeiro, Brazil
2
Instituto de Microbiologia Paulo de Góes (IMPG), Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, Brazil
3
Instituto de Bioquímica Médica (IBqM), Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Del Poeta
Received: 14 October 2016 / Revised: 18 November 2016 / Accepted: 25 November 2016 / Published: 30 November 2016
(This article belongs to the Special Issue Novel Antifungal Drug Discovery)
View Full-Text   |   Download PDF [1364 KB, uploaded 30 November 2016]   |  

Abstract

The global mortality due to cryptococcosis caused by Cryptococcus neoformans or C. gattii is unacceptably high. Currently available therapies are decades old and may be impacted by drug resistance. Therefore, the need for more effective antifungal drugs for cryptococcosis is evident. A number of Cryptococcus virulence factors have been studied in detail, providing crucial information about the fungal biology and putative molecular targets for antifungals. This review focuses on the use of well-described virulence factors of Cryptococcus as potential anticryptococcal agents. View Full-Text
Keywords: C. neoformans; cryptococcosis; virulence factors; anticryptococcal targets C. neoformans; cryptococcosis; virulence factors; anticryptococcal targets
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Azevedo, R.V.D.M.; Rizzo, J.; Rodrigues, M.L. Virulence Factors as Targets for Anticryptococcal Therapy. J. Fungi 2016, 2, 29.

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