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J. Fungi 2015, 1(3), 367-383; doi:10.3390/jof1030367

Pushing the Limits of MALDI-TOF Mass Spectrometry: Beyond Fungal Species Identification

1
Department of Biology, University of Pisa, Via San Zeno 37, 56127 Pisa, Italy
2
Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via San Zeno 37, 56127 Pisa, Italy
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: John R. Perfect
Received: 4 September 2015 / Revised: 5 October 2015 / Accepted: 7 October 2015 / Published: 16 October 2015
(This article belongs to the Special Issue Yeasts Are Beasts)
View Full-Text   |   Download PDF [697 KB, uploaded 16 October 2015]

Abstract

Matrix assisted laser desorption ionization time of flight (MALDI-TOF) is a powerful analytical tool that has revolutionized microbial identification. Routinely used for bacterial identification, MALDI-TOF has recently been applied to both yeast and filamentous fungi, confirming its pivotal role in the rapid and reliable diagnosis of infections. Subspecies-level identification holds an important role in epidemiological investigations aimed at tracing virulent or drug resistant clones. This review focuses on present and future applications of this versatile tool in the clinical mycology laboratory. View Full-Text
Keywords: MALDI-TOF mass spectrometry; fungal diagnosis; drug resistance; biotyping MALDI-TOF mass spectrometry; fungal diagnosis; drug resistance; biotyping
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Rizzato, C.; Lombardi, L.; Zoppo, M.; Lupetti, A.; Tavanti, A. Pushing the Limits of MALDI-TOF Mass Spectrometry: Beyond Fungal Species Identification. J. Fungi 2015, 1, 367-383.

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