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Sinusitis 2016, 1(1), 49-54; doi:10.3390/sinusitis1010049

Chronic Rhinosinusitis as a Crucial Symptom of Cystic Fibrosis—Case Report and Discussion on the Sinonasal Compartment as Site of Pseudomonas aeruginosa Acquisition into CF Airways

1
CF Center, Pediatric Pneumology, Jena University Hospital, Jena 07740, Germany
2
Institute for Medical Microbiology, Jena University Hospital, Jena 07740, Germany
3
Klinische Forschergruppe, Pediatric Pneumology, Med. Hochschule Hannover, Hannover 30625, Germany
4
Pediatric Radiology, Jena University Hospital, Jena 07740, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Claudina A. Pérez Novo
Received: 8 October 2015 / Revised: 22 January 2016 / Accepted: 10 March 2016 / Published: 17 March 2016
(This article belongs to the Special Issue Chronic Rhinosinusitis: Clinical and Immunological Research)
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Abstract

Cystic fibrosis (CF) is the most frequent congenital lethal disease in Caucasians. Impaired mucociliary clearance causes chronic bacterial rhinosinusitis in up to 62% of patients, and almost all patients exhibit sinonasal pathology in CT scans. Pathogens like Pseudomonas aeruginosa (P.a.) chronically colonize about 70% of the CF adults’ lungs and are the major reason for pulmonary destruction and premature death. In our 34-year-old female CF patient, rhinosinusitis caused massive orbital hypertelorism despite three sinonasal operations. Her sputum samples had always been negative for P.a. Then, P.a. was primarily detected in her sputum and additionally in nasal lavage, which since then persisted in both, her upper and lower airways. The P.a. strains turned out to be genetically identical in both airway levels, indicating early colonization of the entire airway system with P.a. This first report on simultaneous primary P.a. detection in the sinonasal and pulmonary compartments highlights the need to include an assessment of upper airway colonization in the standards of CF care, particularly in patients without chronic P.a. colonization. Both airway levels need to be considered as one united system, and a strong cooperation between ENT and CF specialists should be established. Prospective longitudinal studies should assess the upper airways´ role in acquisition and persistence of pathogens and evaluate conservative and surgical therapeutic options. View Full-Text
Keywords: cystic fibrosis; rhinosinusitis; Pseudomonas aeruginosa; upper airways; paranasal sinus; nose; sinus surgery cystic fibrosis; rhinosinusitis; Pseudomonas aeruginosa; upper airways; paranasal sinus; nose; sinus surgery
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Mainz, J.G.; Arnold, C.; Gerber, A.; Rödel, J.; Cramer, N.; Mentzel, H.-J.; Beck, J.F.; Tümmler, B. Chronic Rhinosinusitis as a Crucial Symptom of Cystic Fibrosis—Case Report and Discussion on the Sinonasal Compartment as Site of Pseudomonas aeruginosa Acquisition into CF Airways. Sinusitis 2016, 1, 49-54.

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