Next Article in Journal
Roles of A-Kinase Anchoring Proteins and Phosphodiesterases in the Cardiovascular System
Previous Article in Journal
A-Kinase Anchoring Protein-Lbc: A Molecular Scaffold Involved in Cardiac Protection
Article Menu

Export Article

Open AccessFeature PaperArticle
J. Cardiovasc. Dev. Dis. 2018, 5(1), 13; doi:10.3390/jcdd5010013

Hyperglycemia Alters the Structure and Hemodynamics of the Developing Embryonic Heart

1
Biomedical Engineering Department, Oregon Health & Science University, Portland, OR 97239, USA
2
Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR 97239, USA
*
Author to whom correspondence should be addressed.
Received: 16 December 2017 / Revised: 6 February 2018 / Accepted: 9 February 2018 / Published: 12 February 2018
View Full-Text   |   Download PDF [8077 KB, uploaded 12 February 2018]   |  

Abstract

Congenital heart defects (CHDs) represent the most common form of human birth defects; approximately one-third of heart defects involve malformations of the outflow tract (OFT). Maternal diabetes increases the risk of CHD by 3–5 fold. During heart organogenesis, little is known about the effects of hyperglycemia on hemodynamics, which are critical to normal heart development. Heart development prior to septation in the chick embryo was studied under hyperglycemic conditions. Sustained hyperglycemic conditions were induced, raising the average plasma glucose concentration from 70 mg/dL to 180 mg/dL, akin to the fasting plasma glucose of a patient with diabetes. The OFTs were assessed for structural and hemodynamic alterations using optical coherence tomography (OCT), confocal microscopy, and microcomputed tomography. In hyperglycemic embryos, the endocardial cushions of the proximal OFT were asymmetric, and the OFTs curvature and torsion were significantly altered. The blood flow velocity through the OFT of hyperglycemic embryos was significantly decreased, including flow reversal in 30% of the cardiac cycle. Thus, hyperglycemia at the onset of gestation results in asymmetric proximal endocardial cushions, abnormal OFT curvature, and altered hemodynamics in the developing heart. If present in humans, these results may identify early developmental alterations that contribute to the increased risk for cardiac malformations in babies from diabetic mothers. View Full-Text
Keywords: diabetes; development; congenital heart defect; hemodynamics diabetes; development; congenital heart defect; hemodynamics
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Lawson, T.B.; Scott-Drechsel, D.E.; Chivukula, V.K.; Rugonyi, S.; Thornburg, K.L.; Hinds, M.T. Hyperglycemia Alters the Structure and Hemodynamics of the Developing Embryonic Heart. J. Cardiovasc. Dev. Dis. 2018, 5, 13.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Cardiovasc. Dev. Dis. EISSN 2308-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top