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Open AccessCommunication
J. Cardiovasc. Dev. Dis. 2015, 2(2), 66-75; doi:10.3390/jcdd2020066

Glucose Serum Concentrations and Cardiovascular Disease in Patients on the End Stage of Renal Disease without Diabetes Mellitus

1
Department of Medicine—Propaedaetic, National and Kapodistrian University of Athens, School of Medicine, Athens, 11527, Greece
2
Department of Nuclear Medicine, General Hospital "LAΪKO", Αthens, 11527, Greece
*
Author to whom correspondence should be addressed.
Academic Editor: Andy Wessels
Received: 13 November 2014 / Revised: 20 January 2015 / Accepted: 8 April 2015 / Published: 24 April 2015
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Abstract

Background/Aim: It is still controversial whether tighter glycemic control is associated with better clinical outcomes in patients with kidney failure. We examined the association between glucose serum concentrations and cardiovascular disease in patients on the end stage of renal disease without diabetes mellitus. Methods: We studied 76 patients on on-line hemodiafiltration. Cardiovascular disease was defined by the existence of coronary disease (CD). Arterial stiffness was measured as carotid-femoral pulse wave velocity (c-fPWV) and carotid augmentation index (AIx). The concentrations of beta2-microglobulin (β2M) and insulin were measured by radioimmunoassays and insulin resistance by HOMA-IR. We built a logistic-regression analysis to examine the role of glucose on cardiovascular disease after adjustment for the traditional and specific risk factors for dialysis patients. Results: Serum glucose was positively correlated with beta2M, insulin and HOMA-IR (r = 0.361, p = 0.002, r = 0.581, p = 0.001 and r = 0.753, p = 0.001 respectively). Logistic-regression analysis did not show significant impact of glucose concentrations on cardiovascular disease after adjustment for traditional and specific risk factors. Conclusions: The association between elevated glucose serum concentrations and represented by coronary syndrome cardiovascular disease in patients on the end stage of renal disease without diabetes mellitus was not found significant. View Full-Text
Keywords: glucose; HOMA-IR; cardiovascular disease; hemodiafiltration glucose; HOMA-IR; cardiovascular disease; hemodiafiltration
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Raikou, V.D.; Kyriaki, D. Glucose Serum Concentrations and Cardiovascular Disease in Patients on the End Stage of Renal Disease without Diabetes Mellitus. J. Cardiovasc. Dev. Dis. 2015, 2, 66-75.

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