Next Article in Journal / Special Issue
Left Right Patterning, Evolution and Cardiac Development
Previous Article in Journal / Special Issue
An Introduction to the ESC Working Group on Development, Anatomy and Pathology
Article Menu

Export Article

Open AccessCommunication
J. Cardiovasc. Dev. Dis. 2014, 1(1), 41-51; doi:10.3390/jcdd1010041

miR-27b and miR-23b Modulate Cardiomyocyte Differentiation from Mouse Embryonic Stem Cells

Cardiovascular Development Group, Department of Experimental Biology, University of Jaén, 23071 Jaén, Spain
Author to whom correspondence should be addressed.
Received: 1 February 2014 / Revised: 21 March 2014 / Accepted: 24 March 2014 / Published: 31 March 2014
View Full-Text   |   Download PDF [820 KB, uploaded 31 March 2014]   |  


Diverse types of stem cells represent a potentially attractive source of cardiac cells for the treatment of cardiovascular diseases. However, most of the functional benefits reported for stem cell have been modest and mainly due to paracrine effects rather than differentiation into cardiomyocytes of the applied cells. Therefore, new tools need to be developed in order to improve the efficiency of stem cell differentiation towards specific cardiovascular lineages. Here we show that microRNAs that display early differential expression during ventricular maturation, such as miR-27b, inhibits cardiac differentiation from mouse embryonic stem cells whereas miRNAs that display late differential expression, such as miR-23b, regulates the beating phenotype during in vitro cardiac differentiation from Embryonic Stem Cells (ESCs). This study could have an impact on regenerative medicine since we showed that miR-27b and miR-23b overexpression differentially modify the ESC cell fate towards the cardiac lineage. View Full-Text
Keywords: miR-27b; miR-23b; embryonic stem cells miR-27b; miR-23b; embryonic stem cells

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Vilches, J.M.; Pulido, A.; Hernández-Torres, F.; Franco, D.; Aránega, A. miR-27b and miR-23b Modulate Cardiomyocyte Differentiation from Mouse Embryonic Stem Cells. J. Cardiovasc. Dev. Dis. 2014, 1, 41-51.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
J. Cardiovasc. Dev. Dis. EISSN 2308-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top