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Anterior Hox Genes in Cardiac Development and Great Artery Patterning
J. Cardiovasc. Dev. Dis. 2014, 1(1), 1-2; doi:10.3390/jcdd1010001
Editorial

Cardiovascular Developmental Biology Research— Elucidating Mechanisms Underlying Congenital and Acquired Heart Diseases

Received: 11 September 2013; Accepted: 29 October 2013 / Published: 8 November 2013
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Excerpt: Cardiovascular diseases (CVDs) are the number one cause of death worldwide. According to a recent report from the World Health Organization, an estimated 17.3 million people died from CVDs in 2008, representing 30% of all global deaths. Despite significant advances in surgical approaches and increased survival rate, congenital heart disease (CHD) is still the primary cause of birth defect-related deaths in the western world. More than half of all babies born with a cardiac abnormality will require at least one invasive surgery in their lifetime. As a result of improvement in surgical procedures, many babies who once would have died of CHD now survive into adulthood. In fact, the number of adults with CHD in the USA is now greater than the number of babies born with CHD. However, many adults with congenital heart disease are suffering from functional abnormalities, including arrhythmias and heart failure [1,2] and require lifelong care. The cardiovascular problems can be either intrinsic to the perturbation of developmental events that led to the structural malformations in the first place, or can result from acquired conditions related to scar tissues resulting from the surgical procedures. The primary goals of cardiovascular developmental research are to elucidate the mechanisms that govern normal cardiac development and to determine the molecular and cellular mechanisms involved in the etiology of CHD. In addition, as it becomes increasingly clear that many so-called acquired heart diseases may also have developmental origins, an additional goal of cardiovascular developmental biologists is to identify the early events that may play a role in the pathogenesis of acquired diseases, such as mitral valve prolapse. [...]
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wessels, A. Cardiovascular Developmental Biology Research— Elucidating Mechanisms Underlying Congenital and Acquired Heart Diseases . J. Cardiovasc. Dev. Dis. 2014, 1, 1-2.

AMA Style

Wessels A. Cardiovascular Developmental Biology Research— Elucidating Mechanisms Underlying Congenital and Acquired Heart Diseases . Journal of Cardiovascular Development and Disease. 2014; 1(1):1-2.

Chicago/Turabian Style

Wessels, Andy. 2014. "Cardiovascular Developmental Biology Research— Elucidating Mechanisms Underlying Congenital and Acquired Heart Diseases ." J. Cardiovasc. Dev. Dis. 1, no. 1: 1-2.

J. Cardiovasc. Dev. Dis. EISSN 2308-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert