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Geriatrics 2017, 2(4), 33; doi:10.3390/geriatrics2040033

Evaluation of Drug-Disease Interactions and Their Association with Unplanned Hospital Readmission Utilizing STOPP Version 2 Criteria

School of Pharmacy, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong, China
Author to whom correspondence should be addressed.
Received: 12 October 2017 / Revised: 1 November 2017 / Accepted: 7 November 2017 / Published: 8 November 2017
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Early hospital readmission is a common problem among geriatric patients, as they are more susceptible to adverse drug events, which are associated with increased hospital admission. The objective is to examine the association between exposure to potentially inappropriate medications under selected STOPP version 2 criteria related to drug-disease interactions and unplanned early hospitalization within 28 days of index admission in elderly patients prescribed a potentially inappropriate medication. This retrospective single-center study reviewed patients 75 years of age or older that were discharged with 5 or more medications, including at least one selected medication listed in the STOPP version 2 criteria relating to drug-disease interactions. 182 patients, with a mean age of 83.5 years, were included in the study, with anticholinergics being the most common potentially inappropriate medications (22.4%). Potentially inappropriate medications (57.1% vs. 17.1%, p < 0.001), gout (31% vs. 11.5%, p = 0.003), and gastrointestinal disease (11.9% vs. 2.5%, p = 0.026) were shown to increase risk of 28-day readmission, whereas no other factors assessed correlated with readmission. A rapid evaluation of elderly patient discharge medications and concomitant disease states with the aid of the STOPP version 2 criteria could potentially reduce hospital readmissions or emergency department visits. View Full-Text
Keywords: hospital readmission; drug-disease interaction; potentially inappropriate medications hospital readmission; drug-disease interaction; potentially inappropriate medications

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Lau, M.H.M.; Tenney, J.W. Evaluation of Drug-Disease Interactions and Their Association with Unplanned Hospital Readmission Utilizing STOPP Version 2 Criteria. Geriatrics 2017, 2, 33.

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