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Open AccessCase Report
Vet. Sci. 2017, 4(3), 42; doi:10.3390/vetsci4030042

How Behavioral Changes Can Indicate Serious Cerebral Pathology: A Case Report of Concomitant Olfactory Neuroblastoma and Distemper Virus Encephalitis in a Swiss Shepherd Dog

1
Veterinary practitioner, 10144 Turin, Italy
2
Department of Veterinary Science, University of Turin, 10095 Grugliasco, Italy
3
Graduate Program in Environmental and Experimental Pathology, Paulista University, (UNIP), São Paulo 04313-210, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Emanuela Valle
Received: 29 July 2017 / Revised: 19 August 2017 / Accepted: 22 August 2017 / Published: 28 August 2017
View Full-Text   |   Download PDF [2017 KB, uploaded 28 August 2017]   |  

Abstract

Behavioral alterations in dogs are not easy to understand and cure. The situation is more difficult when an encephalitis due to Canine Distemper Virus (CDV) and a concomitant olfactory neuroblastoma are present. This case report deals with the story of a 5-year-old Swiss shepherd dog with behavioral changes, seizures, epistaxis and ataxia. Following clinical and laboratory exams, a suspected diagnosis of CDV infection was hypothesized, and a therapy based on Ω-interferon was administered. Every supporting therapy failed and the worsening of the clinical conditions led to the euthanasia of the patient. A neoformation in the right frontal lobe was found post mortem. Histopathology and immunohistochemistry investigation showed a non-suppurative demyelinating encephalitis, suggestive of CDV infection, and a desmoplastic epithelioid olfactory neuroblastoma. To the best of authors’ knowledge, this is the first clinical pathological report of a non-suppurative encephalitis due to CDV infection and olfactory neuroblastoma in a dog. View Full-Text
Keywords: brain; canine distemper virus; dog; immunohistochemistry; olfactory neuroblastoma brain; canine distemper virus; dog; immunohistochemistry; olfactory neuroblastoma
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MDPI and ACS Style

Candini, D.; Biasato, I.; Dell’Armelina Rocha, P.R.; Grego, E.; Capucchio, M.T.; Vercelli, C. How Behavioral Changes Can Indicate Serious Cerebral Pathology: A Case Report of Concomitant Olfactory Neuroblastoma and Distemper Virus Encephalitis in a Swiss Shepherd Dog. Vet. Sci. 2017, 4, 42.

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