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Vet. Sci. 2016, 3(4), 31; doi:10.3390/vetsci3040031

Intestinal Organoids—Current and Future Applications

1
Institute of Animal Health and Production, Universidade Federal Rural da Amazônia, Avenida Presidente Tancredo Neves 66077-830, Brazil
2
Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 104, Utrecht 3584 CM, The Netherlands
*
Author to whom correspondence should be addressed.
Academic Editor: Patrick Butaye
Received: 8 August 2016 / Revised: 19 September 2016 / Accepted: 19 October 2016 / Published: 21 October 2016
View Full-Text   |   Download PDF [526 KB, uploaded 21 October 2016]   |  

Abstract

Recent technical advances in the stem cell field have enabled the in vitro generation of complex structures resembling whole organs termed organoids. Most of these approaches employ culture systems that allow stem cell-derived or tissue progenitor cells to self-organize into three-dimensional (3D)-structures. Since organoids can be grown from different species (human, mouse, cat, dog), organs (intestine, kidney, brain, liver), and from patient-derived induced pluripotent stem cells, they create significant prospects for modelling development and diseases, for toxicology and drug discovery studies, and in the field of regenerative medicine. Here, we report on intestinal stem cells, organoid culture, organoid disease modeling, transplantation, specifically covering the current and future uses of this exciting new insight model to the field of veterinary medicine. View Full-Text
Keywords: intestinal organoids; dog; practical applications intestinal organoids; dog; practical applications
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MDPI and ACS Style

Meneses, A.M.C.; Schneeberger, K.; Kruitwagen, H.S.; Penning, L.C.; van Steenbeek, F.G.; Burgener, I.A.; Spee, B. Intestinal Organoids—Current and Future Applications. Vet. Sci. 2016, 3, 31.

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