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Vet. Sci. 2016, 3(1), 7; doi:10.3390/vetsci3010007

Comparative Aspects of Canine Melanoma

1
Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Dr. Orlando Marques de Paiva, 87, CEP 05508-270, São Paulo, Brazil
2
Surgical Oncology Rua Antônio Alves Magan, 124, CEP 01251-150, São Paulo, Brazil
3
Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, CEP 05508-270, São Paulo, Brazil
4
Pathology Veterinary Medicine, FEPI Itajubá University Center, Dr. Antonio Braga Filho Street, 687, Itajubá, 37.501-002 Minas Gerais, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Jaime F. Modiano
Received: 19 August 2015 / Revised: 26 January 2016 / Accepted: 1 February 2016 / Published: 19 February 2016
(This article belongs to the Special Issue Comparative Pathogenesis of Cancers in Animals and Humans)
View Full-Text   |   Download PDF [3457 KB, uploaded 19 February 2016]   |  

Abstract

Melanomas are malignant neoplasms originating from melanocytes. They occur in most animal species, but the dog is considered the best animal model for the disease. Melanomas in dogs are most frequently found in the buccal cavity, but the skin, eyes, and digits are other common locations for these neoplasms. The aim of this review is to report etiological, epidemiological, pathological, and molecular aspects of melanomas in dogs. Furthermore, the particular biological behaviors of these tumors in the different body locations are shown. Insights into the therapeutic approaches are described. Surgery, chemotherapy, radiotherapy, immunotherapy, and the outcomes after these treatments are presented. New therapeutic perspectives are also depicted. All efforts are geared toward better characterization and control of malignant melanomas in dogs, for the benefit of these companion animals, and also in an attempt to benefit the treatment of human melanomas. View Full-Text
Keywords: melanoma; canine; cancer; histopathology; therapy melanoma; canine; cancer; histopathology; therapy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Nishiya, A.T.; Massoco, C.O.; Felizzola, C.R.; Perlmann, E.; Batschinski, K.; Tedardi, M.V.; Garcia, J.S.; Mendonça, P.P.; Teixeira, T.F.; Zaidan Dagli, M.L. Comparative Aspects of Canine Melanoma. Vet. Sci. 2016, 3, 7.

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