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Vet. Sci. 2015, 2(4), 423-439; doi:10.3390/vetsci2040423

Manipulation of Innate Immunity for Cancer Therapy in Dogs

1,2
and
1,2,*
1
Flint Animal Cancer Center, Department of Clinical Sciences, Colorado State University, Ft. Collins, CO 80525, USA
2
The Center for Immune and Regenerative Medicine, Department of Clinical Sciences, Colorado State University, Ft. Collins, CO 80525, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Jaime F. Modiano
Received: 9 October 2015 / Revised: 20 November 2015 / Accepted: 23 November 2015 / Published: 1 December 2015
(This article belongs to the Special Issue Comparative Pathogenesis of Cancers in Animals and Humans)
View Full-Text   |   Download PDF [735 KB, uploaded 1 December 2015]   |  

Abstract

Over the last one to two decades, the field of cancer immunotherapy has rapidly progressed from early preclinical studies to a successful clinical reality and fourth major pillar of human cancer therapy. While current excitement in the field of immunotherapy is being driven by several major breakthroughs including immune checkpoint inhibitors and adoptive cell therapies, these advances stem from a foundation of pivotal studies demonstrating the immune systems role in tumor control and eradication. The following will be a succinct review on veterinary cancer immunotherapy as it pertains to manipulation of the innate immune system to control tumor growth and metastasis. In addition, we will provide an update on recent progress in our understanding of the innate immune system in veterinary tumor immunology, and how these gains may lead to novel therapies for the treatment of cancer in companion animals. View Full-Text
Keywords: innate immunity; cancer; treatment; macrophage; monocyte; dog innate immunity; cancer; treatment; macrophage; monocyte; dog
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Regan, D.; Dow, S. Manipulation of Innate Immunity for Cancer Therapy in Dogs. Vet. Sci. 2015, 2, 423-439.

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