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Vet. Sci. 2015, 2(3), 231-245; doi:10.3390/vetsci2030231

Comparative Aspects of BRAF Mutations in Canine Cancers

1
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
2
Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, NC 27606, USA
3
Center for Human Health and the Environment, North Carolina State University, Raleigh, NC 27606, USA
4
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27514, USA 
*
Author to whom correspondence should be addressed.
Academic Editor: Jaime F. Modiano
Received: 20 July 2015 / Revised: 14 August 2015 / Accepted: 19 August 2015 / Published: 24 August 2015
(This article belongs to the Special Issue Comparative Pathogenesis of Cancers in Animals and Humans)
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Abstract

Activating mutations of the BRAF gene lead to constitutive activation of the MAPK pathway. The characterization and discovery of BRAF mutations in a variety of human cancers has led to the development of specific inhibitors targeting the BRAF/MAPK pathway and dramatically changed clinical outcomes in BRAF-mutant melanoma patients. Recent discovery of BRAF mutation in canine cancers underscores the importance of MAPK pathway activation as an oncogenic molecular alteration evolutionarily conserved between species. A comparative approach using the domestic dog as a spontaneous cancer model will provide new insights into the dysregulation of BRAF/MAPK pathway in carcinogenesis and facilitate in vivo studies to evaluate therapeutic strategies targeting this pathway’s molecules for cancer therapy. The BRAF mutation in canine cancers may also represent a molecular marker and therapeutic target in veterinary oncology. This review article summarizes the current knowledge on BRAF mutations in human and canine cancers and discusses the potential applications of this abnormality in veterinary oncology. View Full-Text
Keywords: dogs; comparative oncology; bladder cancer; urothelial carcinoma; transitional cell carcinoma; mitogen-activated protein kinase dogs; comparative oncology; bladder cancer; urothelial carcinoma; transitional cell carcinoma; mitogen-activated protein kinase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Mochizuki, H.; Breen, M. Comparative Aspects of BRAF Mutations in Canine Cancers. Vet. Sci. 2015, 2, 231-245.

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