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Beverages 2017, 3(1), 17;

Green Tea and Its Extracts in Cancer Prevention and Treatment

Institute of Occupational, Social and Environmental Medicine, Goethe-University Frankfurt/Main, Theodor-Stern-Kai 7, D-60590 Frankfurt/Main, Germany
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Goethe-University, Leimenstrasse 20, D-63450 Hanau, Germany
Author to whom correspondence should be addressed.
Academic Editor: Quan V. Vuong
Received: 1 August 2016 / Revised: 12 January 2017 / Accepted: 1 March 2017 / Published: 15 March 2017
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Green tea (GT) and green tea extracts (GTE) have been postulated to decrease cancer incidence. In vitro results indicate a possible effect; however, epidemiological data do not support cancer chemoprevention. We have performed a PubMED literature search for green tea consumption and the correlation to the common tumor types lung, colorectal, breast, prostate, esophageal and gastric cancer, with cohorts from both Western and Asian countries. We additionally included selected mechanistical studies for a possible mode of action. The comparability between studies was limited due to major differences in study outlines; a meta analysis was thus not possible and studies were evaluated individually. Only for breast cancer could a possible small protective effect be seen in Asian and Western cohorts, whereas for esophagus and stomach cancer, green tea increased the cancer incidence, possibly due to heat stress. No effect was found for colonic/colorectal and prostatic cancer in any country, for lung cancer Chinese studies found a protective effect, but not studies from outside China. Epidemiological studies thus do not support a cancer protective effect. GT as an indicator of as yet undefined parameters in lifestyle, environment and/or ethnicity may explain some of the observed differences between China and other countries. View Full-Text
Keywords: chemoprevention; epidemiology; breast cancer; colorectal cancer; esophageal cancer; gastric cancer; lung cancer; prostatic cancer chemoprevention; epidemiology; breast cancer; colorectal cancer; esophageal cancer; gastric cancer; lung cancer; prostatic cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Schulze, J.; Melzer, L.; Smith, L.; Teschke, R. Green Tea and Its Extracts in Cancer Prevention and Treatment. Beverages 2017, 3, 17.

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