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Beverages 2016, 2(2), 16; doi:10.3390/beverages2020016

The Effect of Dietary Supplementation of Green Tea Catechins on Cardiovascular Disease Risk Markers in Humans: A Systematic Review of Clinical Trials

1
Faculty of Health, University of Canberra, Canberra ACT 2601, Australia
2
Department of Nutrition-Dietetics, School of Health and Education, Harokopio University of Athens, Athens 17671, Greece
3
University of Canberra Health Research Institute (UCHRI), Canberra ACT 2601, Australia
4
University of Canberra Research Institute for Sport and Exercise (UCRISE), Canberra ACT 2601, Australia
5
School of Environmental and Life Sciences, University of Newcastle, Ourimbah NSW 2258, Australia
6
Discipline of Biokinetics, Exercise and Leisure Sciences, School of Health Sciences, University of KwaZulu-Natal, Durban, KwaZulu-Natal 4000, South Africa
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Quan V. Vuong
Received: 29 April 2016 / Revised: 1 June 2016 / Accepted: 10 June 2016 / Published: 21 June 2016
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Abstract

Green tea catechins (GTCs) are secondary plant metabolites that have been associated with health benefits in human trials. As such, they have the potential to reduce cardiovascular disease (CVD) risk; however, results are not consistent. This systematic review of the published data assessed the putative effect of GTCs supplementation on anthropometric, blood pressure, and biochemical measures associated with CVD risk. It was conducted in accordance with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines exploring four major electronic databases (MEDLINE, Cochrane Library, Web of Science, and Scopus). Studies were included if they were published in peer-reviewed journals in English from 1990 until October 2015, and were human double-blind randomized and placebo-controlled trials (RCTs). From 122,428 articles initially identified, after two levels of screening, seven studies met the inclusion criteria. The review revealed consistent and significant (p ≤ 0.05) reductions in body mass index (BMI), blood pressure and plasma lipids; however, this effect would have been less if between-group effects had been considered. The current evidence base also has considerable methodological limitations due to suboptimal statistical methods used in data analyses. Future research efforts must aim to rectify this paucity of evidence with well-designed and well-reported prospective studies. View Full-Text
Keywords: green tea catechins; GTCs; epigallocatechin gallate; EGCG; systematic review; human clinical trials; cardiovascular disease biomarkers green tea catechins; GTCs; epigallocatechin gallate; EGCG; systematic review; human clinical trials; cardiovascular disease biomarkers
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lau, S.O.; Georgousopoulou, E.N.; Kellett, J.; Thomas, J.; McKune, A.; Mellor, D.; Roach, P.D.; Naumovski, N. The Effect of Dietary Supplementation of Green Tea Catechins on Cardiovascular Disease Risk Markers in Humans: A Systematic Review of Clinical Trials. Beverages 2016, 2, 16.

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