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Bioengineering, Volume 8, Issue 9

2021 September - 13 articles

Cover Story: The field of vascular tissue engineering focused on the production of functional small diameter vascular grafts (SDVGs), remains a great challenge. SDVGs are applied to cardiovascular disease (CVD) applications. In this way, modern therapeutic strategies are required to be validated. The use of decellularized human umbilical artery, which will be repopulated with patient’s cells, may represent a valuable approach. Improving the traditional repopulation assays with the use of cord blood platelet lysate, result to better cellularized SDVGs. The application of cellularized SDVGs could contribute to the reduction of global burden of CVD. View this paper
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Articles (13)

  • Communication
  • Open Access
9 Citations
4,790 Views
10 Pages

Polyhydroxybutyrate (PHB) is a very promising alternative to most petroleum-based plastics with the huge advantage of biodegradability. Biotechnological production processes utilizing cyanobacteria as sustainable source of PHB require fast in situ pr...

(This article belongs to the Special Issue Advances in Polyhydroxyalkanoate (PHA) Production, Volume 3)
  • Article
  • Open Access
34 Citations
7,754 Views
21 Pages

The “Federica” Hand

  • Daniele Esposito,
  • Sergio Savino,
  • Emilio Andreozzi,
  • Chiara Cosenza and ,
  • Vincenzo Niola and
  • Paolo Bifulco
  • + 1 author+ 0 author

Hand prostheses partially restore hand appearance and functionalities. In particular, 3D printers have provided great opportunities by simplifying the manufacturing process and reducing costs. The “Federica” hand is 3D-printed and equipped with a sin...

  • Article
  • Open Access
11 Citations
5,534 Views
17 Pages

Thermo-Responsive Hydrogel-Based Soft Valves with Annular Actuation Calibration and Circumferential Gripping

  • Manivannan Sivaperuman Kalairaj,
  • Hritwick Banerjee,
  • Kirthika Senthil Kumar,
  • Keith Gerard Lopez and
  • Hongliang Ren

Valves are largely useful for treatment assistance devices, e.g., supporting fluid circulation movement in the human body. However, the valves presently used in biomedical applications still use materials that are rigid, non-compliant, and hard to in...

  • Case Report
  • Open Access
3 Citations
4,627 Views
5 Pages

Success of Thrombectomy in Management of Ischemic Stroke in Two Patients with SynCardia Total Artificial Heart in Bridge-to-Transplantation

  • Brendan Le Picault,
  • Charles-Henri David,
  • Pierre-Louis Alexandre,
  • Cédric Lenoble and ,
  • Philippe Bizouarn,
  • Thierry Lepoivre,
  • Nicolas Groleau,
  • Bertrand Rozec,
  • Hubert Desal and
  • Thomas Sénage
  • + 6 authors+ 1 author

Introduction: Circulatory assistance from a SynCardia Total Artificial Heart (SynCardia-TAH) is a reliable bridge-to-transplant solution for patients with end-stage biventricular heart failure. Ischemic strokes affect about 10% of patients with a Syn...

(This article belongs to the Special Issue The New Frontiers of Artificial Organs Engineering)
  • Article
  • Open Access
11 Citations
5,510 Views
17 Pages

Vascular smooth muscle cells (VSMCs) remodel vascular walls actively owing to mechanical cues and dedifferentiate to the synthetic phenotype from contractile phenotype in pathological conditions. It is crucial to clarify the mechanisms behind the VSM...

  • Article
  • Open Access
6 Citations
3,881 Views
15 Pages

Mesoporous silica has unique properties such as controllable mesoporous structure and size, good biocompatibility, high specific surface area, and large pore volume. For that reason, this material has been broadly functionalized for biomedical applic...

(This article belongs to the Special Issue Engineered Biomaterials: Design, Modeling, Synthesis, Characterization and Applications)
  • Review
  • Open Access
24 Citations
6,884 Views
34 Pages

Biofabrication Strategies for Musculoskeletal Disorders: Evolution towards Clinical Applications

  • Saman Naghieh,
  • Gabriella Lindberg,
  • Maryam Tamaddon and
  • Chaozong Liu

Biofabrication has emerged as an attractive strategy to personalise medical care and provide new treatments for common organ damage or diseases. While it has made impactful headway in e.g., skin grafting, drug testing and cancer research purposes, it...

(This article belongs to the Special Issue Bioprinting of Tissue-Engineered Scaffolds: Design Strategies & Printability of Smart Biomaterials)
  • Article
  • Open Access
4 Citations
4,683 Views
15 Pages

Amphiphilic and Perfluorinated Poly(3-Hydroxyalkanoate) Nanocapsules for 19F Magnetic Resonance Imaging

  • Marion Le Gal,
  • Estelle Renard,
  • Christelle Simon-Colin,
  • Benoit Larrat and
  • Valérie Langlois

Nanoparticles have recently emerged as valuable tools in biomedical imaging techniques. Here PEGylated and fluorinated nanocapsules based on poly(3-hydroxyalkanoate) containing a liquid core of perfluorooctyl bromide PFOB were formulated by an emulsi...

(This article belongs to the Special Issue Nano-Based Drug Delivery System: Recent Developments and Future Prospects)
  • Article
  • Open Access
21 Citations
5,353 Views
18 Pages

Multiscale Entropy Analysis of Heart Rate Variability in Neonatal Patients with and without Seizures

  • Lorenzo Frassineti,
  • Antonio Lanatà,
  • Benedetta Olmi and
  • Claudia Manfredi

The complex physiological dynamics of neonatal seizures make their detection challenging. A timely diagnosis and treatment, especially in intensive care units, are essential for a better prognosis and the mitigation of possible adverse effects on the...

(This article belongs to the Special Issue Advances in Multivariate Physiological Signal Analysis)
  • Review
  • Open Access
34 Citations
10,104 Views
16 Pages

Autotransplantation of the Third Molar: A Therapeutic Alternative to the Rehabilitation of a Missing Tooth: A Scoping Review

  • Mario Dioguardi,
  • Cristian Quarta,
  • Diego Sovereto,
  • Giuseppe Troiano and ,
  • Michele Melillo,
  • Michele Di Cosola,
  • Angela Pia Cazzolla,
  • Luigi Laino and
  • Lorenzo Lo Muzio
  • + 4 authors+ 0 author

Introduction: Tooth autotransplantation is the repositioning of an erupted, partially erupted, or non-erupted autologous tooth from one site to another within the same individual. Several factors influence the success rate of the autotransplant, such...

  • Review
  • Open Access
42 Citations
12,805 Views
21 Pages

Vaccination is of paramount importance to global health. With the advent of the more recent pandemics, the urgency to expand the range has become even more evident. However, the potential limited availability and affordability of vaccines to resource...

(This article belongs to the Special Issue From Yeast to Biotechnology)
  • Article
  • Open Access
5 Citations
5,201 Views
22 Pages

Improved Repopulation Efficacy of Decellularized Small Diameter Vascular Grafts Utilizing the Cord Blood Platelet Lysate

  • Panagiotis Mallis,
  • Dimitrios P. Sokolis,
  • Michalis Katsimpoulas,
  • Alkiviadis Kostakis and ,
  • Catherine Stavropoulos-Giokas and
  • Efstathios Michalopoulos
  • + 1 author+ 0 author

Background: The development of functional bioengineered small-diameter vascular grafts (SDVGs), represents a major challenge of tissue engineering. This study aimed to evaluate the repopulation efficacy of biological vessels, utilizing the cord blood...

(This article belongs to the Special Issue Modern Approaches in Cardiovascular Disease Therapeutics: From Molecular Genetics to Tissue Engineering)
  • Article
  • Open Access
23 Citations
6,015 Views
14 Pages

Machine Learning Prediction Models for Mitral Valve Repairability and Mitral Regurgitation Recurrence in Patients Undergoing Surgical Mitral Valve Repair

  • Marco Penso,
  • Mauro Pepi,
  • Valentina Mantegazza,
  • Claudia Cefalù and ,
  • Manuela Muratori,
  • Laura Fusini,
  • Paola Gripari,
  • Sarah Ghulam Ali,
  • Enrico G. Caiani and
  • Gloria Tamborini
  • + 5 authors+ 0 author

Background: Mitral valve regurgitation (MR) is the most common valvular heart disease and current variables associated with MR recurrence are still controversial. We aim to develop a machine learning-based prognostic model to predict causes of mitral...

(This article belongs to the Section Regenerative Engineering)
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Bioengineering - ISSN 2306-5354