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Bioengineering 2017, 4(1), 24; doi:10.3390/bioengineering4010024

Optimization of a Diaphragm for a Micro-Shock Tube-Based Drug Delivery Method

Department of Aerospace Engineering, Indian Institute of Science, Bangalore 560012, India
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Author to whom correspondence should be addressed.
Academic Editors: Ramana Pidaparti and Hu Yang
Received: 18 February 2017 / Revised: 6 March 2017 / Accepted: 13 March 2017 / Published: 14 March 2017
(This article belongs to the Special Issue Advanced Drug Delivery Systems and Devices)
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Abstract

This paper presents the design optimization of diaphragms for a micro-shock tube-based drug delivery device. The function of the diaphragm is to impart the required velocity and direction to the loosely held drug particles on the diaphragm through van der Waals interaction. The finite element model-based studies involved diaphragms made up of copper, brass and aluminium. The study of the influence of material and geometric parameters serves as a vital tool in optimizing the magnitude and direction of velocity distribution on the diaphragm surface. Experiments carried out using a micro-shock tube validate the final deformed shape of the diaphragms determined from the finite element simulation. The diaphragm yields a maximum velocity of 335 m/s for which the maximum deviation of the velocity vector is 0.62°. Drug particles that travel to the destination target tissue are simulated using the estimated velocity distribution and angular deviation. Further, a theoretical model of penetration helps in the prediction of the drug particle penetration in the skin tissue like a target, which is found to be 0.126 mm. The design and calibration procedure of a micro-shock tube device to alter drug particle penetration considering the skin thickness and property are presented. View Full-Text
Keywords: drug delivery; needleless; diaphragm; shock tube drug delivery; needleless; diaphragm; shock tube
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Rathod, V.T.; Mahapatra, D.R. Optimization of a Diaphragm for a Micro-Shock Tube-Based Drug Delivery Method. Bioengineering 2017, 4, 24.

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