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Bioengineering 2017, 4(1), 13;

Engineering the RNA-Nanobio Interface

Nanotechnology Innovation Center of Kansas State (NICKS), Department of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, USA
Author to whom correspondence should be addressed.
Academic Editor: Frank Alexis
Received: 21 December 2016 / Revised: 26 January 2017 / Accepted: 8 February 2017 / Published: 15 February 2017
(This article belongs to the Special Issue Nanoparticle Interaction with the Biological Milieu)
View Full-Text   |   Download PDF [2591 KB, uploaded 15 February 2017]   |  


RNA nanotechnology is attracting a great deal of attention recently. As the multiple roles that RNA plays in molecular biology and physiological regulation become clearer, there are many opportunities for engineering RNA-Nanoparticle Complexes (RNA-NPCs). The high “engineerability” of RNA-NPCs comes from the ability to modify the RNA and NP chemistry. For example, the NP can be derived from materials with anticancer activity and the RNA delivered by it, designed to target cell signaling pathways that contribute to the molecular basis of these diseases. Despite this rapid advancement and the availability of new quantification and characterization techniques, a key challenge is to develop a better understanding of the RNA-nanobio interface; that is, the interactions of RNA with NP (RNA-nanobio interface) and how that impacts the structure, function, delivery, and activity of the RNA. Here, we attempt to summarize the state-of-the-art in this new and exciting field, and to lay out potential directions for bioengineering research on RNA-NPCs. View Full-Text
Keywords: RNA-nanoparticle complexes; nano-bio interface; RNA-nanobio interface RNA-nanoparticle complexes; nano-bio interface; RNA-nanobio interface

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Murthy, V.; Delong, R.K. Engineering the RNA-Nanobio Interface. Bioengineering 2017, 4, 13.

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