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Bioengineering 2016, 3(4), 28; doi:10.3390/bioengineering3040028

Preparation and Biocompatible Surface Modification of Redox Altered Cerium Oxide Nanoparticle Promising for Nanobiology and Medicine

1
Physical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia
2
School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore
Academic Editor: Hae-Won Kim
Received: 5 September 2016 / Revised: 21 October 2016 / Accepted: 1 November 2016 / Published: 3 November 2016
View Full-Text   |   Download PDF [1632 KB, uploaded 3 November 2016]   |  

Abstract

The biocompatible surface modification of metal oxide nanoparticles via surface functionalization technique has been used as an important tool in nanotechnology and medicine. In this report, we have prepared aqueous dispersible, trivalent metal ion (samarium)-doped cerium oxide nanoparticles (SmCNPs) as model redox altered CNPs of biological relevance. SmCNP surface modified with hydrophilic biocompatible (6-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-hexyl) triethoxysilane (MEEETES) were prepared using ammonia-induced ethylene glycol-assisted precipitation method and were characterized using a variety of complementary characterization techniques. The chemical interaction of functional moieties with the surface of doped nanoparticle was studied using powerful 13C cross polarization magic angle sample spinning nuclear magnetic resonance spectroscopy. The results demonstrated the production of the extremely small size MEEETES surface modified doped nanoparticles with significant reduction in aggregation compared to their unmodified state. Moreover, the functional moieties had strong chemical interaction with the surface of the doped nanoparticles. The biocompatible surface modification using MEEETES should also be extended to several other transition metal ion doped and co-doped CNPs for the production of aqueous dispersible redox altered CNPs that are promising for nanobiology and medicine. View Full-Text
Keywords: cerium oxide nanoparticle; biocompatible; surface modification; aqueous dispersible; doped and co-doped; nanobiology and medicine cerium oxide nanoparticle; biocompatible; surface modification; aqueous dispersible; doped and co-doped; nanobiology and medicine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Nanda, H.S. Preparation and Biocompatible Surface Modification of Redox Altered Cerium Oxide Nanoparticle Promising for Nanobiology and Medicine. Bioengineering 2016, 3, 28.

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