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Bioengineering 2016, 3(1), 4; doi:10.3390/bioengineering3010004

Transient Mechanical Response of Lung Airway Tissue during Mechanical Ventilation

1
Graduate Student, College of Engineering, University of Georgia, 597 DW Brooks Drive, Athens, GA 30602, USA
2
College of Engineering, University of Georgia, 132A Paul D. Coverdell Center, Athens, GA 30602, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Aldo Boccaccini
Received: 30 September 2015 / Revised: 9 November 2015 / Accepted: 24 December 2015 / Published: 5 January 2016
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Abstract

Patients with acute lung injury, airway and other pulmonary diseases often require Mechanical Ventilation (MV). Knowledge of the stress/strain environment in lung airway tissues is very important in order to avoid lung injuries for patients undergoing MV. Airway tissue strains responsible for stressing the lung’s fiber network and rupturing the lung due to compliant airways are very difficult to measure experimentally. Multi-level modeling is adopted to investigate the transient mechanical response of the tissue under MV. First, airflow through a lung airway bifurcation (Generation 4–6) is modeled using Computational Fluid Dynamics (CFD) to obtain air pressure during 2 seconds of MV breathing. Next, the transient air pressure was used in structural analysis to obtain mechanical strain experienced by the airway tissue wall. Structural analysis showed that airway tissue from Generation 5 in one bifurcation can stretch eight times that of airway tissue of the same generation number but with different bifurcation. The results suggest sensitivity of load to geometrical features. Furthermore, the results of strain levels obtained from the tissue analysis are very important because these strains at the cellular-level can create inflammatory responses, thus damaging the airway tissues. View Full-Text
Keywords: mechanical strains; lung airway; mechanical ventilation; finite element analysis mechanical strains; lung airway; mechanical ventilation; finite element analysis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ibrahim, I.B.M.; Aghasafari, P.; Pidaparti, R.M. Transient Mechanical Response of Lung Airway Tissue during Mechanical Ventilation. Bioengineering 2016, 3, 4.

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