Mesenchymal Stem/Stromal Cell-Derived Small Extracellular Vesicles (MSC-sEVs): A Promising Treatment Modality for Diabetic Foot Ulcer
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References
- Senneville, É.; Lipsky, B.A.; Abbas, Z.G.; Aragón-Sánchez, J.; Diggle, M.; Embil, J.M.; Kono, S.; Lavery, L.A.; Malone, M.; van Asten, S.A.; et al. Diagnosis of infection in the foot in diabetes: A systematic review. Diabetes Metab. Res. Rev. 2020, 36 (Suppl. S1), e3281. [Google Scholar] [CrossRef] [PubMed]
- Cavanagh, P.R.; Lipsky, B.A.; Bradbury, A.W.; Botek, G. Treatment for diabetic foot ulcers. Lancet 2005, 366, 1725–1735. [Google Scholar] [CrossRef]
- Caplan, A.I.; Correa, D. The MSC: An Injury Drugstore. Cell Stem Cell 2011, 9, 11–15. [Google Scholar] [CrossRef]
- Domínguez-Bendala, J.; Lanzoni, G.; Inverardi, L.; Ricordi, C. Concise review: Mesenchymal stem cells for diabetes. Stem Cells Transl. Med. 2012, 1, 59–63. [Google Scholar] [CrossRef]
- Rai, V.; Moellmer, R.; Agrawal, D.K. Stem Cells and Angiogenesis: Implications and Limitations in Enhancing Chronic Diabetic Foot Ulcer Healing. Cells 2022, 11, 2287. [Google Scholar] [CrossRef] [PubMed]
- Bernardo, M.E.; Fibbe, W.E. Mesenchymal Stromal Cells: Sensors and Switchers of Inflammation. Cell Stem Cell 2013, 13, 392–402. [Google Scholar] [CrossRef] [PubMed]
- Mahmoudvand, G.; Rouzbahani, A.K.; Razavi, Z.S.; Mahjoor, M.; Afkhami, H. Mesenchymal stem cell therapy for non-healing diabetic foot ulcer infection: New insight. Front. Bioeng. Biotechnol. 2023, 11, 1158484. [Google Scholar] [CrossRef] [PubMed]
- Kouroupis, D.; Bowles, A.C.; Willman, M.A.; Orfei, C.P.; Colombini, A.; Best, T.M.; Kaplan, L.D.; Correa, D. Infrapatellar fat pad-derived MSC response to inflammation and fibrosis induces an immunomodulatory phenotype involving CD10-mediated Substance P degradation. Sci. Rep. 2019, 9, 10864. [Google Scholar] [CrossRef] [PubMed]
- Li, D.; Wu, N. Mechanism and application of exosomes in the wound healing process in diabetes mellitus. Diabetes Res. Clin. Pract. 2022, 187, 109882. [Google Scholar] [CrossRef] [PubMed]
- Dorronsoro, A.; Santiago, F.E.; Grassi, D.; Zhang, T.; Lai, R.C.; McGowan, S.J.; Angelini, L.; Lavasani, M.; Corbo, L.; Lu, A.; et al. Mesenchymal stem cell-derived extracellular vesicles reduce senescence and extend health span in mouse models of aging. Aging Cell 2021, 20, e13337. [Google Scholar] [CrossRef] [PubMed]
- Kouroupis, D.; Kaplan, L.D.; Best, T.M. Human infrapatellar fat pad mesenchymal stem cells show immunomodulatory exosomal signatures. Sci. Rep. 2022, 12, 3609. [Google Scholar] [CrossRef] [PubMed]
- Kouroupis, D.; Kaplan, L.D.; Huard, J.; Best, T.M. CD10-Bound Human Mesenchymal Stem/Stromal Cell-Derived Small Extracellular Vesicles Possess Immunomodulatory Cargo and Maintain Cartilage Homeostasis under Inflammatory Conditions. Cells 2023, 12, 1824. [Google Scholar] [CrossRef] [PubMed]
- Leñero, C.; Kaplan, L.D.; Best, T.M.; Kouroupis, D. CD146+ Endometrial-Derived Mesenchymal Stem/Stromal Cell Subpopulation Possesses Exosomal Secretomes with Strong Immunomodulatory miRNA Attributes. Cells 2022, 11, 4002. [Google Scholar] [CrossRef] [PubMed]
- Garima; Sharma, D.; Kumar, A.; Mostafavi, E. Extracellular vesicle-based biovectors in chronic wound healing: Biogenesis and delivery approaches. Mol. Ther.—Nucleic Acids 2023, 32, 822–840. [Google Scholar] [CrossRef] [PubMed]
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Kouroupis, D.; Kaplan, L.D.; Ricordi, C.; Best, T.M. Mesenchymal Stem/Stromal Cell-Derived Small Extracellular Vesicles (MSC-sEVs): A Promising Treatment Modality for Diabetic Foot Ulcer. Bioengineering 2023, 10, 1140. https://doi.org/10.3390/bioengineering10101140
Kouroupis D, Kaplan LD, Ricordi C, Best TM. Mesenchymal Stem/Stromal Cell-Derived Small Extracellular Vesicles (MSC-sEVs): A Promising Treatment Modality for Diabetic Foot Ulcer. Bioengineering. 2023; 10(10):1140. https://doi.org/10.3390/bioengineering10101140
Chicago/Turabian StyleKouroupis, Dimitrios, Lee D. Kaplan, Camillo Ricordi, and Thomas M. Best. 2023. "Mesenchymal Stem/Stromal Cell-Derived Small Extracellular Vesicles (MSC-sEVs): A Promising Treatment Modality for Diabetic Foot Ulcer" Bioengineering 10, no. 10: 1140. https://doi.org/10.3390/bioengineering10101140