Biopharmaceutical Process Optimization with Simulation and Scheduling Tools
AbstractDesign and assessment activities associated with a biopharmaceutical process are performed at different levels of detail, based on the stage of development that the product is in. Preliminary “back-of-the envelope” assessments are performed early in the development lifecycle, whereas detailed design and evaluation are performed prior to the construction of a new facility. Both the preliminary and detailed design of integrated biopharmaceutical processes can be greatly assisted by the use of process simulators, discrete event simulators or finite capacity scheduling tools. This report describes the use of such tools for bioprocess development, design, and manufacturing. The report is divided into three sections. Section One provides introductory information and explains the purpose of bioprocess simulation. Section Two focuses on the detailed modeling of a single batch bioprocess that represents the manufacturing of a therapeutic monoclonal antibody (MAb). This type of analysis is typically performed by engineers engaged in the development and optimization of such processes. Section Three focuses on production planning and scheduling models for multiproduct plants. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Petrides, D.; Carmichael, D.; Siletti, C.; Koulouris, A. Biopharmaceutical Process Optimization with Simulation and Scheduling Tools. Bioengineering 2014, 1, 154-187.
Petrides D, Carmichael D, Siletti C, Koulouris A. Biopharmaceutical Process Optimization with Simulation and Scheduling Tools. Bioengineering. 2014; 1(4):154-187.Chicago/Turabian Style
Petrides, Demetri; Carmichael, Doug; Siletti, Charles; Koulouris, Alexandros. 2014. "Biopharmaceutical Process Optimization with Simulation and Scheduling Tools." Bioengineering 1, no. 4: 154-187.