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Medicines 2018, 5(1), 1; https://doi.org/10.3390/medicines5010001

The Determination of Blood Glucose Lowering and Metabolic Effects of Mespilus germanica L. Hydroacetonic Extract on Streptozocin-Induced Diabetic Balb/c Mice

1
Student Research Committee, Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari 4847193698, Iran
2
Department of Pharmacognosy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari 4847193698, Iran
3
Medicinal Plants Research Center, Ayatollah Amoli Branch, Islamic Azad University, Amol 4635143358, Iran
4
Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari 4847193698, Iran
5
Thalassamia Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari 4847193698, Iran
*
Author to whom correspondence should be addressed.
Received: 20 October 2017 / Revised: 29 December 2017 / Accepted: 29 December 2017 / Published: 1 January 2018
(This article belongs to the Special Issue Medicinal Plants and Foods)
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Abstract

Background: The serum glucose lowering, normalization animal body weight, and antioxidative stress effects of Mespilus germanica L. leaf extract were investigated in normal and streptozotocin-induced Balb/C mice. Methods: The phenol and flavonoid of the leaves of M. germanica were extracted by percolation and concentrated using a rotary evaporator. Its total phenol and flavonoid content was determined using folin and aluminum chloride methods, respectively. The study was conducted on 48 matured male Balb/C mice (20–30 g) divided into 6 groups (n = 8). Diabetes mellitus was induced by single intraperitoneal injection of 35 mg/kg of streptozotocin (STZ). Extracts of Mespilus germanica were used orally at the dose of 50, 100, and 200 mg/kg body weight per day for 21 days. Results: Oral administrations of the M. germanica L. leaf extract significantly decreased serum glucose, oxidative stress, and lipid peroxidation and maintained animal body weight during treatment period (p < 0.05) compared to metformin (200 mg/kg) in over 100 mg/kg, 200 mg/kg, and 50 mg/kg dosages, respectively. Conclusions: The present study indicated that the Mespilus germanica leaf extract significantly decreased serum glucose and maintained normal body weight in Balb/C diabetic mice. View Full-Text
Keywords: flavonoids; diabetes; Rosaceae; Mespilus germanica; mice flavonoids; diabetes; Rosaceae; Mespilus germanica; mice
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Shafiee, F.; Khoshvishkaie, E.; Davoodi, A.; Dashti Kalantar, A.; Bakhshi Jouybari, H.; Ataee, R. The Determination of Blood Glucose Lowering and Metabolic Effects of Mespilus germanica L. Hydroacetonic Extract on Streptozocin-Induced Diabetic Balb/c Mice. Medicines 2018, 5, 1.

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