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Foods 2015, 4(2), 130-139; doi:10.3390/foods4020130

A Prospective Randomized Double-Blind Study Evaluating UP165 and S-Adenosyl-l-Methionine on Depression, Anxiety and Psychological Well-Being

1
Miami Research Associates, Endocrinology and Nutrition Department, 6141 Sunset Drive, Suite 301, Miami, FL 33143, USA
2
Miami Research Associates, Neurosciences Department, 6141 Sunset Drive, Suite 301, Miami, FL 33143, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Rotimi Aluko
Received: 20 March 2015 / Revised: 24 April 2015 / Accepted: 29 April 2015 / Published: 8 May 2015
View Full-Text   |   Download PDF [101 KB, uploaded 8 May 2015]

Abstract

The primary objective of this pilot clinical trial was to evaluate the effects of UP165 (derived from Zea mays L., commonly known as corn) over time. The secondary objective was the comparison for outcomes versus S-adenosyl-methionine (SAM-e). Subjects with mild depression or anxiety were given the Beck Depression Inventory second edition (BDI-II), the Beck Anxiety Inventory (BAI), and the Schwartz Outcome Scale (SOS-10). Forty-two subjects (21–65 years old) were randomized to eight-weeks of supplementation with UP165 or SAM-e with questionnaires being administered at randomization, week four and eight. Those receiving UP165 achieved significant reduction from baseline at weeks four and eight, respectively for the BDI-II, as well as a trend for reduction in BAI at week four and significance at week eight. There was a trend for improvement on the SOS at week four and significance at week eight. SAM-e demonstrated a trend for improvement on the BDI-II by week eight over the UP165 with no differences between the two for the BAI or the SOS. Overall, this study indicates that there may be benefit to UP165 for mood enhancement in those with mild depression or anxiety. Randomized placebo comparator trials appear warranted. View Full-Text
Keywords: depression; anxiety; dietary supplement; S-adenosyl-methionine(SAM-e); Zea mays L. depression; anxiety; dietary supplement; S-adenosyl-methionine(SAM-e); Zea mays L.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kalman, D.S.; Feldman, S.; Vazquez, R.R.; Krieger, D.R. A Prospective Randomized Double-Blind Study Evaluating UP165 and S-Adenosyl-l-Methionine on Depression, Anxiety and Psychological Well-Being. Foods 2015, 4, 130-139.

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