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Dent. J. 2018, 6(3), 27; https://doi.org/10.3390/dj6030027

Evaluation of an In Situ Hardening β-Tricalcium Phosphate Graft Material for Alveolar Ridge Preservation. A Histomorphometric Animal Study in Pigs

1
Laboratory of Experimental Surgery and Surgical Research N. S. Christeas, Medical School, University of Athens, 75 M. Assias Street, 115 27 Athens, Greece
2
Department of Pathology, Medical School, University of Athens, 75 M. Assias Street, 115 27 Athens, Greece
3
Department of Periodontology and Implant Dentistry, School of Dentistry, University of Detroit Mercy, 2700 Martin Luther King Jr Boulevard, Detroit, MI 48208, USA
4
Department of Oral and Maxillofacial Surgery, Dental School, University of Athens, 2 Thivon Street, 115 27 Athens, Greece
5
Departments of Periodontics, Implant Dentistry, and Oral Surgery, New York University College of Dentistry, 345 E 24th Street, New York, NY 10010, USA
*
Author to whom correspondence should be addressed.
Received: 21 April 2018 / Revised: 1 June 2018 / Accepted: 6 June 2018 / Published: 2 July 2018
(This article belongs to the Special Issue Soft and Hard Tissue Regeneration)
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Abstract

The purpose of this study was to investigate the effectiveness of a resorbable alloplastic in situ hardening bone grafting material for alveolar ridge preservation in a swine model. Seven Landrace pigs were used. In each animal, the maxillary left and right deciduous second molars were extracted, and extraction sites were either grafted with a resorbable alloplastic in situ hardening bone substitute, composed of beta-tricalcium phosphate (β-TCP) granules coated with poly(lactic-co-glycolic) acid (PLGA), or left unfilled to heal spontaneously. Animals were euthanized after 12 weeks, and the bone tissue was analyzed histologically and histomorphometrically. Linear changes of ridge width were also clinically measured and analyzed. Pronounced bone regeneration was found in both experimental and control sites, with no statistically significant differences. At the experimental sites, most of the alloplastic grafting material was resorbed and remnants of the graft particles were severely decreased in size. Moreover, experimental sites showed, in a statistically nonsignificant way, less mean horizontal dimensional reduction of the alveolar ridge (7.69%) compared to the control sites (8.86%). In conclusion, the β-TCP/PLGA biomaterial performed well as a biocompatible resorbable in situ hardening bone substitute when placed in intact extraction sockets in this animal model. View Full-Text
Keywords: Alveolar ridge preservation; β-tricalcium phosphate; bone regeneration; bone substitutes; animal study Alveolar ridge preservation; β-tricalcium phosphate; bone regeneration; bone substitutes; animal study
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Leventis, M.; Agrogiannis, G.; Fairbairn, P.; Vasiliadis, O.; Papavasileiou, D.; Theodoropoulou, E.; Horowitz, R.; Kalyvas, D. Evaluation of an In Situ Hardening β-Tricalcium Phosphate Graft Material for Alveolar Ridge Preservation. A Histomorphometric Animal Study in Pigs. Dent. J. 2018, 6, 27.

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