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Dent. J. 2018, 6(2), 6; https://doi.org/10.3390/dj6020006

Effect of Violet-Blue Light on Streptococcus mutans-Induced Enamel Demineralization

1
Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, Indianapolis, IN 46202, USA
2
Department of Cariology, Operative Dentistry and Dental Public Health, Indiana University School of Dentistry, Indianapolis, IN 46202, USA
3
Department of Operative Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA
4
Department of Biostatistics, Indiana University, Indianapolis, IN 46202, USA
*
Authors to whom correspondence should be addressed.
Received: 18 February 2018 / Revised: 15 March 2018 / Accepted: 16 March 2018 / Published: 21 March 2018
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Abstract

Background: This in vitro study determined the effectiveness of violet-blue light (405 nm) on inhibiting Streptococcus mutans-induced enamel demineralization. Materials and Methods: S. mutans UA159 biofilm was grown on human enamel specimens for 13 h in 5% CO2 at 37 °C with/without 1% sucrose. Wet biofilm was treated twice daily with violet-blue light for five minutes over five days. A six-hour reincubation was included daily between treatments excluding the final day. Biofilms were harvested and colony forming units (CFU) were quantitated. Lesion depth (L) and mineral loss (∆Z) were quantified using transverse microradiography (TMR). Quantitative light-induced fluorescence Biluminator (QLF-D) was used to determine mean fluorescence loss. Data were analyzed using one-way analysis of variance (ANOVA) to compare differences in means. Results: The results demonstrated a significant reduction in CFUs between treated and non-treated groups grown with/without 1% sucrose. ∆Z was significantly reduced for specimens exposed to biofilms grown without sucrose with violet-blue light. There was only a trend on reduction of ∆Z with sucrose and with L on both groups. There were no differences in fluorescence-derived parameters between the groups. Conclusions: Within the limitations of the study, the results indicate that violet-blue light can serve as an adjunct prophylactic treatment for reducing S. mutans biofilm formation and enamel mineral loss. View Full-Text
Keywords: violet-blue light; phototherapy; Streptococcus mutans; dental caries violet-blue light; phototherapy; Streptococcus mutans; dental caries
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Felix Gomez, G.G.; Lippert, F.; Ando, M.; Zandona, A.F.; Eckert, G.J.; Gregory, R.L. Effect of Violet-Blue Light on Streptococcus mutans-Induced Enamel Demineralization. Dent. J. 2018, 6, 6.

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