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Dent. J. 2016, 4(2), 17; doi:10.3390/dj4020017

Diabetes Mellitus and Its Association to the Occurrence of Medication-Related Osteonecrosis of the Jaw

Department of Oral and Maxillofacial Surgery of the University Medical Center of the Johannes Gutenberg-University, Augustusplatz 2, 55131 Mainz, Germany
Author to whom correspondence should be addressed.
Academic Editor: Patrick R. Schmidlin
Received: 17 April 2016 / Revised: 22 May 2016 / Accepted: 24 May 2016 / Published: 31 May 2016
(This article belongs to the Special Issue New Cancer and Osteoporosis Therapies and Osteocrosis of the Jaws)
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To date there is no consensus on the role of diabetes in the development of medication-related osteonecrosis of the jaws (MR-ONJ). Therefore, this study aimed to investigate the prevalence of diabetes and pathological glucose metabolism in patients with MR-ONJ compared to the general population. All maxillofacial surgery inpatients in one year at our department were investigated regarding diagnosis, anamnesis, medication, and blood glucose readings. 1374 records were analyzed. 35 patients with MR-ONJ were identified. Diabetics accounted for 14.3%. No significant difference in the prevalence of known diabetes was found, except for pathological glucose metabolism in patients with MR-ONJ (p < 0.001). Diabetes does not necessarily promote the onset of MR-ONJ. Therefore, diabetes should not be considered as a standalone risk factor. On the contrary, hyperglycemia as a possible indicator for poorly managed or yet undetected diabetes is associated with MR-ONJ. View Full-Text
Keywords: diabetes; hyperglycemia; bisphosphonates; denosumab; MR-ONJ; BP-ONJ diabetes; hyperglycemia; bisphosphonates; denosumab; MR-ONJ; BP-ONJ
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Rahimi-Nedjat, R.K.; Sagheb, K.; Pabst, A.; Olk, L.; Walter, C. Diabetes Mellitus and Its Association to the Occurrence of Medication-Related Osteonecrosis of the Jaw. Dent. J. 2016, 4, 17.

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