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Dent. J. 2016, 4(1), 4; doi:10.3390/dj4010004

Infection and Pulp Regeneration

Division of Endodontics, Columbia University College of Dental Medicine, 630 W. 168th St. PH7Stem #128, New York, NY 10032, USA
Academic Editor: Louis M. Lin
Received: 1 January 2016 / Revised: 3 March 2016 / Accepted: 4 March 2016 / Published: 10 March 2016
(This article belongs to the Special Issue Regeneration and Repair in Endodontics)
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Abstract

The regeneration of the pulp-dentin complex has been a great challenge to both scientists and clinicians. Previous work has shown that the presence of prior infection may influence the characteristics of tissues formed in the root canal space after regenerative endodontic treatment. The formation of ectopic tissues such as periodontal ligament, bone, and cementum has been observed in the root canal space of immature necrotic teeth with apical periodontitis, while the regeneration of dentin and pulp has been identified in previously non-infected teeth. The current regenerative endodontic therapy utilizes disinfection protocols, which heavily rely on chemical irrigation using conventional disinfectants. From a microbiological point of view, the current protocols may not allow a sufficiently clean root canal microenvironment, which is critical for dentin and pulp regeneration. In this article, the significance of root canal disinfection in regenerating the pulp-dentin complex, the limitations of the current regenerative endodontic disinfection protocols, and advanced disinfection techniques designed to reduce the microorganisms and biofilms in chronic infection are discussed. View Full-Text
Keywords: infection; disinfection; pulp regeneration; regenerative endodontics; the pulp-dentin complex; dentinal tubule; immune response; biofilm infection; disinfection; pulp regeneration; regenerative endodontics; the pulp-dentin complex; dentinal tubule; immune response; biofilm
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kim, S.G. Infection and Pulp Regeneration. Dent. J. 2016, 4, 4.

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