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Dent. J. 2015, 3(4), 93-101; doi:10.3390/dj3040093

Management of Antithrombotic Agents in Oral Surgery Maria Martinez and Dimitrios A. Tsakiris *

Diagnostic Hematology, University Hospital Basel, CH-4031 Basel, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editor: Claude Jaquiéry
Received: 21 August 2015 / Revised: 13 September 2015 / Accepted: 23 September 2015 / Published: 6 October 2015
(This article belongs to the Special Issue Medically Compromised Patients in Dentistry)
View Full-Text   |   Download PDF [278 KB, uploaded 6 October 2015]

Abstract

Systemic anticoagulation with intravenous or oral anticoagulants and antiplatelet agents is an efficient treatment against thromboembolic or cardiovascular disease. Invasive dental procedures or oral surgery might be associated with bleeding complications if carried out under anticoagulants. Patients on vitamin K antagonists, new direct anticoagulants or antiplatelet agents having dental interventions with low-risk for bleeding do not need interruption of anticoagulation. In case of bleeding complications local hemostatic measures, such as local surgical sutures, fibrin glue, local antifibrinolytic treatment with tranexamic acid, or e-aminocaproic acid suffice to stop bleeding. In patients with high risk of bleeding an individual assessment of the benefit/risk ratio of interrupting anticoagulation should be carried out. Bridging the long-term anticoagulation with short-term anticoagulants should be planned according to national or international guidelines. The introduction of the newer direct oral anticoagulants having more flexible pharmacokinetic properties has facilitated bridging, allowing short-term interruption without increasing the risk of relapsing thrombotic or cardiovascular events. View Full-Text
Keywords: oral anticoagulants; dental surgery; oral surgery; DOAC; direct oral anticoagulants; NOAC; new oral anticoagulants; heparins; antiplatelet agents oral anticoagulants; dental surgery; oral surgery; DOAC; direct oral anticoagulants; NOAC; new oral anticoagulants; heparins; antiplatelet agents
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Martinez, M.; Tsakiris, D.A. Management of Antithrombotic Agents in Oral Surgery Maria Martinez and Dimitrios A. Tsakiris *. Dent. J. 2015, 3, 93-101.

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Dent. J. EISSN 2304-6767 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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