Mineralization of Early Stage Carious Lesions In Vitro—A Quantitative Approach
AbstractMicro computed tomography has been combined with dedicated data analysis for the in vitro quantification of sub-surface enamel lesion mineralization. Two artificial white spot lesions, generated on a human molar crown in vitro, were examined. One lesion was treated with a self-assembling peptide intended to trigger nucleation of hydroxyapatite crystals. We non-destructively determined the local X-ray attenuation within the specimens before and after treatment. The three-dimensional data was rigidly registered. Three interpolation methods, i.e., nearest neighbor, tri-linear, and tri-cubic interpolation were evaluated. The mineralization of the affected regions was quantified via joint histogram analysis, i.e., a voxel-by-voxel comparison of the tomography data before and after mineralization. After ten days incubation, the mean mineralization coefficient reached 35.5% for the peptide-treated specimen compared to 11.5% for the control. This pilot study does not give any evidence for the efficacy of peptide treatment nor allows estimating the necessary number of specimens to achieve significance, but shows a sound methodological approach on the basis of the joint histogram analysis. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Deyhle, H.; Dziadowiec, I.; Kind, L.; Thalmann, P.; Schulz, G.; Müller, B. Mineralization of Early Stage Carious Lesions In Vitro—A Quantitative Approach. Dent. J. 2015, 3, 111-122.
Deyhle H, Dziadowiec I, Kind L, Thalmann P, Schulz G, Müller B. Mineralization of Early Stage Carious Lesions In Vitro—A Quantitative Approach. Dentistry Journal. 2015; 3(4):111-122.Chicago/Turabian Style
Deyhle, Hans; Dziadowiec, Iwona; Kind, Lucy; Thalmann, Peter; Schulz, Georg; Müller, Bert. 2015. "Mineralization of Early Stage Carious Lesions In Vitro—A Quantitative Approach." Dent. J. 3, no. 4: 111-122.