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Photonics 2016, 3(2), 31; doi:10.3390/photonics3020031

Liver Status Assessment by Spectrally and Time Resolved IR Detection of Drug Induced Breath Gas Changes

1
Department of Experimental Physics, Free University Berlin, Arnimallee 14, 14195 Berlin, Germany
2
Department of General, Visceral and Transplantation Surgery, Charité-Universitätsmedizin, 13353 Berlin, Germany
3
Department of General, Visceral, Vascular and Pediatric Surgery, University Hospital of Wuerzburg, Josef-Schneider-Straße 2, 97080 Wuerzburg, Germany
*
Author to whom correspondence should be addressed.
Received: 31 March 2016 / Revised: 28 April 2016 / Accepted: 30 April 2016 / Published: 20 May 2016
(This article belongs to the Special Issue Quantum Cascade Lasers - Advances and New Applications)
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Abstract

The actual metabolic capacity of the liver is crucial for disease identification, liver therapy, and liver tumor resection. By combining induced drug metabolism and high sensitivity IR spectroscopy of exhaled air, we provide a method for quantitative liver assessment at bedside within 20 to 60 min. Fast administration of 13C-labelled methacetin induces a fast response of liver metabolism and is tracked in real-time by the increase of 13CO2 in exhaled air. The 13CO2 concentration increase in exhaled air allows the determination of the metabolic liver capacity (LiMAx-test). Fluctuations in CO2 concentration, pressure and temperature are minimized by special gas handling, and tracking of several spectrally resolved CO2 absorption bands with a quantum cascade laser. Absorption measurement of different 12CO2 and 13CO2 rotation-vibration transitions in the same time window allows for multiple referencing and reduction of systematic errors. This FLIP (Fast liver investigation package) setup is being successfully used to plan operations and determine the liver status of patients. View Full-Text
Keywords: QCL; liver status; 13CO2; breath test; LiMAx; rotation-vibration spectroscopy QCL; liver status; 13CO2; breath test; LiMAx; rotation-vibration spectroscopy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Rubin, T.; von Haimberger, T.; Helmke, A.; Lock, J.; Stockmann, M.; Heyne, K. Liver Status Assessment by Spectrally and Time Resolved IR Detection of Drug Induced Breath Gas Changes. Photonics 2016, 3, 31.

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