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Photonics 2014, 1(1), 9-32; doi:10.3390/photonics1010009

Instrumentation in Diffuse Optical Imaging

Department of Radiology, Duke University Medical Center, DUMC 3808, Durham, NC 27710, USA
Received: 15 December 2013 / Revised: 6 January 2014 / Accepted: 7 January 2014 / Published: 20 March 2014
(This article belongs to the Special Issue Biomedical Optics and Optical Imaging)
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Diffuse optical imaging is highly versatile and has a very broad range of applications in biology and medicine. It covers diffuse optical tomography, fluorescence diffuse optical tomography, bioluminescence and a number of other new imaging methods. These methods of diffuse optical imaging have diversified instrument configurations, but share the same core physical principle: light propagation in highly diffusive media, i.e., biological tissue. In this review, the author summarizes the latest development in instrumentation and methodology available to diffuse optical imaging in terms of system architecture, light source, photo-detection, spectral separation, signal modulation and, lastly, imaging contrast.
Keywords: diffuse optical imaging; instrumentation; fluorescence; molecular imaging; bioluminescence; tomography; clinical; preclinical diffuse optical imaging; instrumentation; fluorescence; molecular imaging; bioluminescence; tomography; clinical; preclinical
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zhang, X. Instrumentation in Diffuse Optical Imaging. Photonics 2014, 1, 9-32.

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