Theoretical and Experimental Approaches Aimed at Drug Design Targeting Neurodegenerative Diseases
, Laura Sánchez-Aros 4, Oscar Forero-Doria 5, Wendy González 4,6, Nuria E. Campilllo 7, Miguel Reyes-Parada 8,9, Ana Martínez 7 and David Ramírez 10,*Round 1
Reviewer 1 Report
Drug development for neurodegenerative diseases have been challenging. New strategies and perspectives are needed to move the field forward.
Green chemistry and computational chemistry are experiencing rapid development in recent years. Here, the authors are proposing harnessing the two approaches as potential strategy in developing therapeutic agent against polypharmacologic targets.
In this review article, the authors have selected relevant studies and examples to illustrate their proposition. This is useful as not all readers are "well" trained in chemical synthesis. Nonetheless, the reading can still be hard for biologists.
Author Response
Dear reviewer, thanks for your comment, the writing style was reviewed and improved in order to make the manuscript easy to read for biologists.
Reviewer 2 Report
Processes
Nov 17, 19
Title: Theoretical and experimental approaches aimed at the drug design targeting neurodegenerative diseases
Samuel Morales-Navarro1, Luis Prent-Peñaloza2, Yeray A. Rodriguez Núñez3, Laura Sánchez-Aros4, Oscar Forero-Doria5, Wendy González4,6, Nuria E. Campilllo7, Miguel Reyes-Parada8,9, Ana Martínez7 and David Ramírez10,*
The manuscript by Morales-Navarro et al. “Theoretical and experimental approaches aimed at the drug design targeting neurodegenerative diseases” is a potential nice review and would contribute to the literature in the related fields. Generally speaking, this manuscript is well written. However, it can be strengthened by addessing the following issues.
The authors need to describe the molecular mechanisms for each of the main neurodegenerative diseases and major targets for them; thus, the authors can specifically discuss what drugs need to be designed. The authors need to discuss what need to be done for these fields at this moment. Are the approaches described in the manuscripts better than others?
Author Response
Dear reviewer, thanks for your comment, the molecular mechanisms for each of the main neurodegenerative diseases and major targets for them were described in the section 3: Drug design and discovery targeting NDD. (pag 12). We also discussed what need to be done for these fields nowadays in section 4, as well as if the approaches described in the review are better than others in section 3 and 4.
Round 2
Reviewer 2 Report
The authors have adequately addressed my concerns. They may think of more targets for PD and other ND diseases such as Huntington disease for drugs.
Author Response
Dear reviewer, thanks for your comment. We included Huntington disease and discussed how some authors are designing new bioactive compounds targeting this disease. (see Section 3 – page 14).
