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Processes 2017, 5(3), 50; doi:10.3390/pr5030050

Synthesis of Water-Soluble Group 4 Metallocene and Organotin Polyethers and Their Ability to Inhibit Cancer

1
Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA
2
Department of Biology, University of Texas Arlington, Arlington, TX 76010, USA
*
Author to whom correspondence should be addressed.
Received: 7 August 2017 / Revised: 24 August 2017 / Accepted: 26 August 2017 / Published: 1 September 2017
(This article belongs to the Special Issue Water Soluble Polymers)
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Abstract

Water-soluble metallocene and organotin-containing polyethers were synthesized employing interfacial polycondensation. The reaction involved various chain lengths of poly(ethylene glycol), and produced water-soluble polymers in decent yield. Commercially available reactants were used to allow for easy scale up. The polymers exhibited a decent ability to inhibit a range of cancer cell lines, including two pancreatic cancer cell lines. This approach should allow the synthesis of a wide variety of other water-soluble polymers. View Full-Text
Keywords: Group 4 metallocenes; anticancer; poly(ethylene glycol); pancreatic cancer; breast cancer; prostate cancer; interfacial polycondensation; Group 4 metallocene polymers; organotin polyethers Group 4 metallocenes; anticancer; poly(ethylene glycol); pancreatic cancer; breast cancer; prostate cancer; interfacial polycondensation; Group 4 metallocene polymers; organotin polyethers
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Carraher, C.E.; Roner, M.R.; Frank, J.; Moric-Johnson, A.; Miller, L.C.; Black, K.; Slawek, P.; Mosca, F.; Einkauf, J.D.; Russell, F. Synthesis of Water-Soluble Group 4 Metallocene and Organotin Polyethers and Their Ability to Inhibit Cancer. Processes 2017, 5, 50.

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