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Informatics 2014, 1(1), 72-99; doi:10.3390/informatics1010072
Review

Molecular Imaging of Bacterial Infections in vivo: The Discrimination between Infection and Inflammation

 and
*
Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USA
* Author to whom correspondence should be addressed.
Received: 18 March 2014 / Revised: 6 May 2014 / Accepted: 13 May 2014 / Published: 30 May 2014
(This article belongs to the Special Issue Biomedical Imaging and Visualization)
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Abstract

Molecular imaging by definition is the visualization of molecular and cellular processes within a given system. The modalities and reagents described here represent a diverse array spanning both pre-clinical and clinical applications. Innovations in probe design and technologies would greatly benefit therapeutic outcomes by enhancing diagnostic accuracy and assessment of acute therapy. Opportunistic pathogens continue to pose a worldwide threat, despite advancements in treatment strategies, which highlights the continued need for improved diagnostics. In this review, we present a summary of the current clinical protocol for the imaging of a suspected infection, methods currently in development to optimize this imaging process, and finally, insight into endocarditis as a model of infectious disease in immediate need of improved diagnostic methods.
Keywords: molecular imaging; endocarditis; infection; inflammation; Staphylococcus aureus molecular imaging; endocarditis; infection; inflammation; Staphylococcus aureus
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Eggleston, H.; Panizzi, P. Molecular Imaging of Bacterial Infections in vivo: The Discrimination between Infection and Inflammation. Informatics 2014, 1, 72-99.

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