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Biomedicines 2018, 6(3), 79; https://doi.org/10.3390/biomedicines6030079

Pathogens and Their Effect on Exosome Biogenesis and Composition

1
Microbiology Program, Department of Biological Sciences, College of Science, Technology, Engineering and Mathematics, Alabama State University, Montgomery, AL 36104, USA
2
Department of Biological Sciences, College of Science, Technology, Engineering and Mathematics, Alabama State University, Montgomery, AL 36104, USA
3
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
4
Center for NanoBiotechnology Research and Department of Biological Sciences, Alabama State University, Montgomery, AL 36104, USA
*
Author to whom correspondence should be addressed.
Received: 25 May 2018 / Revised: 17 July 2018 / Accepted: 17 July 2018 / Published: 23 July 2018
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Abstract

Exosomes are nanosized membrane microvesicles (30–100 nm) that have the capability to communicate intercellularly and transport cell components (i.e., miRNA, mRNA, proteins and DNA). Exosomes are found in nearly every cell type (i.e., mast cells, dendritic, tumor, and macrophages). There have been many studies that have shown the importance of exosome function as well as their unique packaging and targeting abilities. These characteristics make exosomes ideal candidates to act as biomarkers and therapeutics for disease. We will discuss the biogenesis, composition, and relationship of exosomes with non-viral microbial infections including gram-negative bacteria, gram-positive bacteria, Leishmania and Trypanosoma cruzi. View Full-Text
Keywords: exosomes; Trypanosoma cruzi; bacteria; leishmaniasis; biomarker exosomes; Trypanosoma cruzi; bacteria; leishmaniasis; biomarker
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Jones, L.B.; Bell, C.R.; Bibb, K.E.; Gu, L.; Coats, M.T.; Matthews, Q.L. Pathogens and Their Effect on Exosome Biogenesis and Composition. Biomedicines 2018, 6, 79.

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