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Biomedicines 2018, 6(3), 77; https://doi.org/10.3390/biomedicines6030077

Breast Cancer Stem Cells

Department of Genetics and the Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
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Received: 26 June 2018 / Revised: 13 July 2018 / Accepted: 14 July 2018 / Published: 17 July 2018
(This article belongs to the Special Issue Stem Cells and Cancer Therapeutics)
View Full-Text   |   Download PDF [263 KB, uploaded 17 July 2018]   |  

Abstract

Breast cancer stem cells (BCSC) have been implicated in tumor initiation, progression, metastasis, recurrence, and resistance to therapy. The origins of BCSCs remain controversial due to tumor heterogeneity and the presence of such small side populations for study, but nonetheless, cell surface markers and their correlation with BCSC functionality continue to be identified. BCSCs are driven by persistent activation of developmental pathways, such as Notch, Wnt, Hippo, and Hedgehog and new treatment strategies that are aimed at these pathways are in preclinical and clinical development. View Full-Text
Keywords: breast cancer; stem cells; Notch; Wnt; Hedgehog; Hippo breast cancer; stem cells; Notch; Wnt; Hedgehog; Hippo
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Crabtree, J.S.; Miele, L. Breast Cancer Stem Cells. Biomedicines 2018, 6, 77.

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