Noncanonical NF-κB in Cancer
AbstractThe NF-κB pathway is a critical regulator of immune responses and is often dysregulated in cancer. Two NF-κB pathways have been described to mediate these responses, the canonical and the noncanonical. While understudied compared to the canonical NF-κB pathway, noncanonical NF-κB and its components have been shown to have effects, usually protumorigenic, in many different cancer types. Here, we review noncanonical NF-κB pathways and discuss its important roles in promoting cancer. We also discuss alternative NF-κB-independent functions of some the components of noncanonical NF-κB signaling. Finally, we discuss important crosstalk between canonical and noncanonical signaling, which blurs the two pathways, indicating that understanding the full picture of NF-κB regulation is critical to deciphering how this broad pathway promotes oncogenesis. View Full-Text
Share & Cite This Article
Tegowski, M.; Baldwin, A. Noncanonical NF-κB in Cancer. Biomedicines 2018, 6, 66.
Tegowski M, Baldwin A. Noncanonical NF-κB in Cancer. Biomedicines. 2018; 6(2):66.Chicago/Turabian Style
Tegowski, Matthew; Baldwin, Albert. 2018. "Noncanonical NF-κB in Cancer." Biomedicines 6, no. 2: 66.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.