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Biomedicines 2018, 6(2), 47; https://doi.org/10.3390/biomedicines6020047

Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms

1
Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Crown Street, Liverpool L697ZB, UK
2
Department of Biochemistry, Institute of Biomedical Research, Autonomous Madrid University, Arturo Duperier, 4. 28029 Madrid, Spain
*
Author to whom correspondence should be addressed.
Received: 28 February 2018 / Revised: 26 March 2018 / Accepted: 19 April 2018 / Published: 22 April 2018
(This article belongs to the Special Issue Hypoxia)
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Abstract

Hypoxia or reduced oxygen availability has been studied extensively for its ability to activate specific genes. Hypoxia-induced gene expression is mediated by the HIF transcription factors, but not exclusively so. Despite the extensive knowledge about how hypoxia activates genes, much less is known about how hypoxia promotes gene repression. In this review, we discuss the potential mechanisms underlying hypoxia-induced transcriptional repression responses. We highlight HIF-dependent and independent mechanisms as well as the potential roles of dioxygenases with functions at the nucleosome and DNA level. Lastly, we discuss recent evidence regarding the involvement of transcriptional repressor complexes in hypoxia. View Full-Text
Keywords: hypoxia; chromatin; transcriptional repression; repressor Complexes; JmjC; histone methylation; HIF hypoxia; chromatin; transcriptional repression; repressor Complexes; JmjC; histone methylation; HIF
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Batie, M.; del Peso, L.; Rocha, S. Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms. Biomedicines 2018, 6, 47.

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