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Biomedicines 2017, 5(4), 71; https://doi.org/10.3390/biomedicines5040071

Histology of Non-Melanoma Skin Cancers: An Update

1
Dermatology and Cosmetology, IRCCS San Raffaele Hospital, 20132 Milan, Italy
2
Department of Dermatology, Dipartimento di Medicina Interna e Specialità Mediche, La Sapienza University of Rome, 00161 Rome, Italy
3
Department of Pathology, Università Campus Biomedico, 00161 Rome, Italy
4
First Division of Dermatology, IRCCS Istituto Dermopatico dell’Immacolata, 00161 Rome, Italy
5
Unità Operativa Complessa of Dermatology, Policlinico Umberto I, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy
*
Author to whom correspondence should be addressed.
Received: 9 November 2017 / Revised: 11 December 2017 / Accepted: 19 December 2017 / Published: 20 December 2017
(This article belongs to the Special Issue Photodynamic Therapy in Cancer)
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Abstract

Non-melanoma skin cancer (NMSC) is the most frequently diagnosed cancer in humans. Several different non-melanoma skin cancers have been reported in the literature, with several histologic variants that frequently cause important differential diagnoses with other cutaneous tumors basal cell carcinoma (BCC) is the most common malignant skin tumor, with different histologic variants that are associated with a greater or less aggressive behavior and that usually may be confused with other primitive skin tumors. Actinic keratosis, Bowen’s disease, keratoacanthoma, and invasive squamous cell carcinoma (SCC) correspond to the other line of NMSC, that may have only local tumoral behavior, easy to treat and with local management (as in the case of actinic keratosis (AK), Bowen’s disease, and keratoacanthoma) or a more aggressive behavior with a potential metastatic spread, as in case of invasive SCC. Therefore, histopathology serves as the gold standard during daily clinical practice, in order to improve the therapeutical approaches to patients with NMSC and to understand the distinct histopathological features of NMSC. Here, we reported the main pathological features of different non-melanoma skin cancers. View Full-Text
Keywords: non-melanoma skin cancers; basal cell carcinoma; squamous cell carcinoma; diagnosis; pathology non-melanoma skin cancers; basal cell carcinoma; squamous cell carcinoma; diagnosis; pathology
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Paolino, G.; Donati, M.; Didona, D.; Mercuri, S.R.; Cantisani, C. Histology of Non-Melanoma Skin Cancers: An Update. Biomedicines 2017, 5, 71.

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