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Biomedicines 2017, 5(4), 63; doi:10.3390/biomedicines5040063

In Vitro and In Vivo Biological Activities of Cissus adnata (Roxb.)

1
Pharmacognosy and Phytochemistry Lab, Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh
2
Drug Discovery, GUSTO A Research Group, Chittagong 4000, Bangladesh
3
Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4000, Bangladesh
4
Department of Biotechnology and Genetic Engineering, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 9 October 2017 / Revised: 25 October 2017 / Accepted: 26 October 2017 / Published: 30 October 2017
(This article belongs to the Special Issue Plant Derived Biomedicines)
View Full-Text   |   Download PDF [1956 KB, uploaded 30 October 2017]   |  

Abstract

This study was conducted to evaluate the in vitro polyphenol content, antioxidant, cytotoxic, antibacterial, anthelmintic properties, and in vivo antinociceptive activity of the ethanol extract of Cissus adnata leaves (EECA) in different experimental models. Polyphenol contents were investigated using spectrophotometric techniques. Antioxidant activity was determined by 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) radical-scavenging, ferric reducing power, and total antioxidant capacity assays. Cytotoxicity was determined by brine shrimp lethality bioassay and disc diffusion method was used for the antibacterial activity. Anthelmintic activity was studied using aquarium worm (Tubifex tubifex) whereas antinociceptive activity was evaluated in mice by acetic acid and formalin test. Phytochemical screening of EECA revealed the presence of alkaloids, carbohydrates, flavonoids, phenols, terpenoids, saponins, and tannins. EECA showed strong antioxidant activity with high polyphenol contents. It was observed that EECA possessed significant antibacterial activity with a low toxicity profile. EECA also demonstrated dose-dependent and statistically significant anthelmintic and antinociceptive activities. Our study shows that ethanol extract of C. adnata leaves possess strong antioxidant, antibacterial, anthelmintic and antinociceptive activities with lower toxicity. Further studies are needed to identify bioactive phytomolecules and to understand the mechanism of such actions better. View Full-Text
Keywords: polyphenol; antioxidant; cytotoxic; antibacterial; anthelmintic; antinociceptive; Cissus adnata polyphenol; antioxidant; cytotoxic; antibacterial; anthelmintic; antinociceptive; Cissus adnata
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Shoibe, M.; Chy, M.N.U.; Alam, M.; Adnan, M.; Islam, M.Z.; Nihar, S.W.; Rahman, N.; Suez, E. In Vitro and In Vivo Biological Activities of Cissus adnata (Roxb.). Biomedicines 2017, 5, 63.

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