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Biomedicines 2017, 5(2), 27; doi:10.3390/biomedicines5020027

NF-κB in Hematological Malignancies

Centre Méditerranéen de Médecine Moléculaire, INSERM U1065, Université Côte d’Azur, 06204 Nice, France
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Author to whom correspondence should be addressed.
Academic Editor: Véronique Baud
Received: 28 April 2017 / Revised: 24 May 2017 / Accepted: 26 May 2017 / Published: 31 May 2017
(This article belongs to the Special Issue Roles of NF-kB in Cancer and Their Therapeutic Approaches)
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Abstract

NF-κB (Nuclear Factor Κ-light-chain-enhancer of activated B cells) transcription factors are critical regulators of immunity, stress response, apoptosis, and differentiation. Molecular defects promoting the constitutive activation of canonical and non-canonical NF-κB signaling pathways contribute to many diseases, including cancer, diabetes, chronic inflammation, and autoimmunity. In the present review, we focus our attention on the mechanisms of NF-κB deregulation in hematological malignancies. Key positive regulators of NF-κB signaling can act as oncogenes that are often prone to chromosomal translocation, amplifications, or activating mutations. Negative regulators of NF-κB have tumor suppressor functions, and are frequently inactivated either by genomic deletions or point mutations. NF-κB activation in tumoral cells is also driven by the microenvironment or chronic signaling that does not rely on genetic alterations. View Full-Text
Keywords: NF-κB; leukemia; lymphoma NF-κB; leukemia; lymphoma
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Imbert, V.; Peyron, J.-F. NF-κB in Hematological Malignancies. Biomedicines 2017, 5, 27.

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